current thesis topics in pathology

Hematopathology/Immunohematology/Flow Cytometry

Effect of Ultraviolet B Light on Antibody Production to the Hapten Dinitrophenyl in a Murine Model

Flow Cytometric Evaluation of P-Glycoprotein Associated Multi-drug Resistance in Acute Leukemia Patients at Diagnosis Using Monoclonal Antibody 4E3

Flow Cytometric DNA Analysis of Mantle Cell Lymphoma: Clinicopathologic and Immunophenotypic Correlates

Flow Cytometric Determination of P-Glycoprotein Expression on Blast Cells from Pediatric Leukemia Patients

Factor VIIa as a Predictor of Thromboembolic Events

Microbiology/Immunology

Interactions of Streptococcus mutans Fimbriae Binding with Salivary Components Characterization of the Colonization Factor Antigen 1 (CFA/1) Operon Encoding CFA/1 Fimbriae of Enterotoxigenic Escherichia coli.

Candida and Cryptococcus Semi-automated Antifungal Susceptibility Testing Utilizing the Bactec 9240J

The Effect of IL-2 in HIV-infected Individuals Vaccinated with Tetanus Toxoid, using CD69 and BvdU Uptake to measure Lymphocyte Responsiveness

Enhanced Detection of Coagulase Negative Staphylococcus in Pediatric Blood Cultures

Characterization of Polyclonal Anti-peptidoglycan Antibodies that Differentiate Between Cell Wall Fragments of Gram-Negative Bacteria and Gram-Positive Bacteria by Enzyme Inhibition Assay

Immunology of Murine Pneumocystis carinii Infection

RAPD PCR DNA Fingerprinting on Sequential Isolates of Histoplasma capsulatum from AIDS Patients Failing Fluconazole Therapy

Typing of Pneumocystis carinii f. sp. hominis Isolates and Effects of Pneumocystis carinii Infection on Host Gene Expression

Effects of Pneumocystis carinii on Alveolar Macrophage Function during Infection

Serum and Secretory IgA Immunity in HIV-1 Infection

The Pneumocystis carinii Cyst: Infectivity and Role in Damage in a Rat Mode of Infection

Diagnosis of Trichomonas vaginalis: a Comparison of Existing and Experimental Diagnostic Tests for Routine Clinical Use

Cytopathology/Anatomic Pathology

Biochemical Pattern-Targeted Anticancer Drug Treatment

Familial Adenomatous Polyposis: A Genotype – Phenotype Correlation

Flow Cytometric Analysis of DNA Ploidy Correlated with 14q Allelic Imbalance in Renal Cell Carcinoma

A Study of Reproductive Tissue of pcd Mutant Mice

Evaluation of Smooth Muscle Cell Proliferation and Apoptosis after Intramural Heparin Delivery with Hydrogel-coated Balloons

Molecular Evidence for the Independent Origin of Extra-Ovarian Tumors in Advanced Stage Ovarian *Papillary Serous Tumors of Low Malignant Potential

Characterization of Antibodies Produced to the Novel Carboxyl-terminus of the Inv Protein

FHIT Expression in Prostatic Tumors

Home > FACULTIES > Pathology > PATHOL-ETD

Pathology Theses and Dissertations

This collection contains theses and dissertations from the Department of Pathology, collected from the Scholarship@Western Electronic Thesis and Dissertation Repository

Theses/Dissertations from 2024 2024

The role of gut microbiome on the immunogenicity of immune hot neuroblastoma tumours , Hasti Gholami

Theses/Dissertations from 2023 2023

Investigation of Novel Pan-RAF Inhibitors in Anaplastic Thyroid Cancer , Sarah EB Ryan

Theses/Dissertations from 2022 2022

Evaluating the utility of S100A7 in identifying oral dysplastic lesions that will progress to oral squamous cell carcinoma , Jeff Soparlo

Theses/Dissertations from 2021 2021

Investigating The Impact Of The COVID-19 Pandemic On Maternal Perceived Stress, Postpartum Depressive Symptoms, And Pregnancy Outcomes In London, Ontario: A One Health Approach , Mei Yuan

Theses/Dissertations from 2020 2020

Evidence of an Antigen Presenting Cell Phenotype in Granular Cell Tumours , Benjamin J W A Rogala

Theses/Dissertations from 2019 2019

Junctophilin-2 Protects Cardiomyocytes against Palmitate-induced Injury , Xiaoyun Ji

Evaluating the Utility of Protein Biomarker, S100A7, and Diagnostic Test, Straticyte, in Predicting the Progression of Oral Dysplasia , Lachlan McLean

Alpha-Synuclein Toxicity is Caused by Mitochondrial Dysfunction , Michael G. Tauro

Theses/Dissertations from 2018 2018

Non-Cancerous Abnormalities That Could Mimic Prostate Cancer Like Signal in Multi-Parametric MRI Images , Mena Gaed

Mitochondrial permeability regulates cardiac endothelial cell necroptosis and cardiac allograft rejection , Ingrid Gan

Kallikrein-Related Peptidases are Dysregulated in Pleomorphic Adenoma , Matthew D. Morrison

Increased Mitochondrial Calpain-1 Is an Important Mechanism Contributing to Mitochondrial ROS Generation in Cardiac Diseases , Rui Ni

Elucidating mechanisms of innate and acquired resistance to PI3Ka inhibition in head and neck squamous cell carcinoma , Kara M. Ruicci

The Effects of Child Restraint System Use and Motor Vehicle Collision Severity on Injury Patterns and Severity in Children 8 Years Old and Younger. , Peyton A. Schroeder

Role of Long Noncoding RNAs in Diabetic Complications , Anu Alice Thomas

Effect of Estrogen and Glucocorticoid Signaling on Th2 cells – Implications for Severe Asthma , Meerah Vijeyakumaran

Theses/Dissertations from 2017 2017

CRISPR Screen for Identification of Kinases that Mediate Prostate Cancer Cell Invasion , Hamad Aldhafeeri

Immunological Impact of CLI-095 on Dendritic Cell Maturation and Hypoxia-re-oxygenation induced inflammatory injury , Hajed Obaid Alharbi

ERK5 Expression in Brain Tumours , Reem Ansari

Expression of Human Tissue Kallikreins (KLKs) in Polymorphous Low Grade Adenocarcinoma (PLGA) , Jacqueline M. Cox

A Clinico-Pathological Study of the Structural and Functional Changes in the Retina and Optic Nerve Following Diabetic Retinopathy Treatments , Richard Filek

Mechanisms underlying chemotherapy-induced vascular proliferation in ovarian cancer , Zeynep Gülsüm Kahramanoğlu

The Effect of Glucocorticosteroids on Th2 cells , Tharsan Kanagalingam

Hsp90 and its Co-chaperones Modify TDP-43 Localization, Aggregation, and Toxicity , Lilian T. Lin

Characterization of Hemangioma-initiating Stem Cells , Natalie Montwill

Postnatal β1 Integrin Deficiency in Pancreatic Beta-Cells Impairs Function and Survival , Jason E. Peart

Up-regulation of junctophilin-2 prevents ER stress and apoptosis in hypoxia/reoxygenation-stimulated H9c2 cells , Zijun Su

Theses/Dissertations from 2016 2016

Body and Organ Measurements in Infants and Neonates: An Autopsy Study , Audrey-Ann M. Evetts

The Long Non-coding RNA Malat1 Regulates Inflammatory Cytokine Production in Chronic Diabetic Complications , Andrew D. Gordon

Expression of Kallikrein-Related Peptidases (KLKs) in Adenoid Cystic Carcinoma , Zachary R. Kerr

Mechanisms regulating stem cell phenotype in infantile hemangioma , Niamh Richmond

Etiology of Motor Vehicle Collision Fatalities in Urban and Rural Canada , James R. Roos

Identification of a Nuclear Localization Signal (NLS) within the Pleckstrin Homology (PH) domain of Rho Guanine Nucleotide Exchange Factor (RGNEF) , Michael V. Tavolieri

Development and Performance Evaluation of an Antibody-Based Technology for Detection of E. coli O157 in Meat Samples and Its Potential Evolution Using Antibody Engineering , Yadira Tejeda Saldaña

Regulation of Phosphatase and Tensin Homolog Expression and Activity by Transforming Growth-Factor Beta in the Trabecular Meshwork Cells: Implications for Primary Open Angle Glaucoma , Nikoleta Tellios

Theses/Dissertations from 2015 2015

Phase II Clinical Trial of Concurrent Neoadjuvant Chemotherapy With Radiotherapy in Locally Advanced Breast Cancer , Muriel Brackstone

Expression Of Human Kallikrein Protein And mRNA In Maxillofacial Cysts And Tumours , Karl Kevin Cuddy

Chromatin Structure and Differential Accessibility of Homologous Human Mitotic Metaphase Chromosomes , Wahab A. Khan

β-adrenergic receptor-dependent and -independent effects of propranolol in infantile hemangioma , Jina J.Y. Kum

CD4+ T-cell Mediated Microvascular Endothelial Cell Death and Chronic Cardiac Allograft Rejection Involves Necroptosis , Cecilia YT Kwok

Epithelial to mesenchymal transition in the metastatic progression of gastroenteropancreatic neuroendocrine tumours , Stephanie Mok

Protective Effect of Modified Human Fibroblast Growth Factor on Diabetic Nephropathy , Ana M. Pena Diaz

Diabetic Bone Marrow & Stem Cell Dysfunction , Meghan A. Piccinin

Investigation of Pancreatic β-Cell Insulin Receptor Regulation of β-Cell Growth, Function, and Survival Via a Temporal Conditional Knockout , Liangyi Zhou

Theses/Dissertations from 2014 2014

The Role Of The RNA-Binding Protein Rho Guanine Nucleotide Exchange Factor In The Cellular Stress Response , Kevin WH Cheung

Exposure to Environmental Contaminants and Stress as Determinants of Health in Three Communities: Walpole Island and Attawapiskat First Nations and Naivasha, Kenya , Deirdre Phaedra Henley

miRNA Regulation of Programmed Cell Death-1 in T Cells: Potential Prognostic and Therapeutic Markers in Melanoma , Nathan J. Johnston

Cell Death Regulates Injury and Inflammation During Renal Allograft Transplantation , Arthur Lau

Role of SIRT1 in Vascular Complications of Diabetes , Rokhsana Mortuza

RIPK3 Regulates Microvascular Endothelial Cell Necroptosis and Cardiac Allograft Rejection , Alexander William Pavlosky

The Role of Integrins in Support of Pancreatic Function, Survival and Maturation , Matthew Riopel

Polycomb Repressive Complex 2 Regulates miR-200b in Retinal Endothelial Cells: Possible Implications in Diabetic Retinopathy , Michael A. Ruiz

Association of Head and Cervical Injuries in Pediatric Occupants Involved in Motor Vehicle Collisions , Shayan Shekari

Development of Non-Covalent Functionalization of Carbon Nanotubes for siRNA Delivery , King Sun Siu

The Expression and Potential Significance of Human Kallikreins 6, 7, 8, 10, 13, and 14 in the Epithelium of Selected Odontogenic Cysts and Tumors of Variably Aggressive Biological Behaviour , Rebecca Woodford

Theses/Dissertations from 2013 2013

Targeted siRNA Delivery Methods for RNAi-Based Therapies , Di Chen

Elucidating the Role of Menin During Islet Cell Development in the Human Fetal Pancreas , Jessica L. Dubrick

Vascular Stem Cells in Diabetic Complications , Emily C. Keats

Theses/Dissertations from 2012 2012

Immunohistochemical Studies of Expression and Correlation of Osteopontin, CD44, and Integrin αVβ3 in Selected Benign and Malignant Salivary Gland Tumours , Tommy Fok

The role of non-canonical Wnt/planar cell polarity signalling in breast cancer progression , Connor D. MacMillan

Elucidating the Function of Transplanted Islets of Langerhans and Predicting Their Ability to Reverse Diabetes , Andrew R. Pepper

Role of ERK5 in Diabetic Vascular Complications , Yuexiu Wu

Regulation of NK cell-mediated tubular epithelial cell death and kidney ischemia-reperfusion injury by the NKR-P1B receptor and Clr-b , James Yip

Theses/Dissertations from 2011 2011

A Model System for Rapid Identification and Functional Testing of Genes Involved in Early Breast Cancer Progression , Lesley H. Souter

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Digital Commons @ USF > USF Health > College of Medicine > Pathology and Cell Biology > Theses and Dissertations

Pathology and Cell Biology Theses and Dissertations

Theses/dissertations from 2024 2024.

Elucidating the role of the tumor suppressor gene RNA-binding motif 5 (RBM5) in models of traumatic brain injury , Kara L. Snyder

Theses/Dissertations from 2023 2023

A Novel Role for eNOS in Regulating Lymphatic Valve Development During Embryogenesis , Drishya Iyer

Bioinformatic Analysis Predicts Microglial Dysfunction in Murine Aging , Amadu Idrisa Jalloh

Withaferin A and Immune Checkpoint Blocker Therapy for the Treatment of Non-Small Cell Lung Cancer , Roukiah Khalil

Vascular and Auditory Changes after Repetitive Traumatic Brain Injury , Courtney Lynn Penn

Theses/Dissertations from 2022 2022

Neural and Cardiac Mechanisms in Friedreich's Ataxia with Patient-derived iPSCs , Mariana Burgos Angulo

Atrial Fibrillation in Aging: Mechanisms and Potential Therapeutics , Mengmeng Chang

Effect of Hyperoxia on Cardiac Pathophysiology in Female Guinea Pig Hearts , Chayapatou Chayawatto

Role of BMI1 in Acute Lung Injury , María Helena Hernández-Cuervo

Screening Pathological Protein Specific Antibodies as Biomarker Discovery Tools for Neurodegenerative Disease , Yitong Li

Reelin Supplementation for the Rescue of Fragile X Syndrome. , Nicole K. Morrill

Small heat shock protein 22 preserves neuronal function in a murine model of tauopathy , Santiago Rodriguez Ospina

Phenotypic Variability in iPSC-Induced Cardiomyocytes and Cardiac Fibroblasts Carrying Diverse LMNA Mutations , Jiajia Yang

X-linked Ubiquitin-Specific Peptidase 11 Increases Tauopathy Vulnerability in Women , Yan Yan

Theses/Dissertations from 2021 2021

Hyperoxia-Induced Cardiac Pathophysiology in Guinea Pig Hearts , Zain ul Abidin

Activity-dependent Regulation of Extracellular UBE3A in a Novel Angelman Syndrome Rat Model , Andie Dodge

Contribution of Retinal Ganglion Cells to Brown-Norway Rat Spatiotemporal Visual Perception and the Electroretinogram , Nicholas P. Johnson

Mechanistic Insight into β-Lactamase Catalysis, Inhibitor Design and Resistance , Michael Trent Kemp

Application of Gold Nanoshells for Photothermal Therapy in Lung Cancer Cells , Yva K. Luc

Drug Candidates Targeting Hsp90/Cdc37 for the Treatment of Neurodegenerative Disease , Ryan Martin

A Study of TRPA1 Activation via Covalent Electrophilic Modification of Cysteines , Thomas A. Parks

Targeting Modern Pathogens with Rational Drug Design , Michael Dominic Sacco

Effects of Exogenous Ketone Therapy on Performance, Cardiorespiration, and Seizure Genesis During Exposure to HBO2 in the Sprague Dawley Rat , Nicole M. Stavitzski

Role of NHE3 in the intestine and thick ascending limb of the kidneys , Jianxiang Xue

Metastatic MAT Phenotype Driven by Noncanonical EphA2 Signaling in Melanoma , Chao Zhang

Theses/Dissertations from 2020 2020

Hyaluronic Acid Coated Targeted Lipid Micellar Nanoparticle as a Delivery Vehicle for Lapatinib and Ketoconazole in EGFR mutated Lung Cancer , Nadia Tasnim Ahmed

Structure Based Inhibitor Discovery Targeting Multiple β-Lactamases Involved in Antibiotic Resistance , Afroza Akhtar

SSH1 Impedes p62/SQSTM1 Flux and Tau Clearance Independent of Cofilin Activation , Cenxiao Fang

Testing Glutathione-S-Transferase Mu 1 (GSTM1) in Protecting Retinal Pigment Epithelium Cells from Oxidative Stress , Inyoung C. Garner

Role of Thyroid Hormone Modulating Astrocyte Activation , Payal Ghosh

Synthesis of a Targeted pH Responsive Nanoparticle for Controlled Release of Actinomycin D , Alejandro Jesus Gonzalez

Discovery and Characterization of Small Molecule Inhibitors of Bromodomains , Md Rezaul Karim

Targeting Cancer-Anorexia Cachexia Syndrome and Septic Inflammatory-Based Atrophy With R/S 1,3 Butanediol Acetoacetate Diester , Andrew P. Koutnik

Cognition in Health and Disease: Two Mouse Model Studies , Heather Lynn Mahoney

Functional Significance of Endothelial Sigma-1 Receptors in Vascular Reactivity and Barrier Function , Zeinab Y. Motawe

Mass Spectrometry Discovery-Based Proteomics to Examine Anti-Aging Effects of the Nutraceutical NT-020 in Rat Serum , Samantha M. Portis

Dendriplex - Cyclodextrin conjugates for Gene delivery to Retina , Durga Deepak Puro

Immune Modulation as a Therapeutic Target in an α-synuclein Model of Parkinson’s Disease , Meena Subhashini Subbarayan

Role of Serum Amyloid P Component in the Pathogenesis of Chronic Traumatic Encephalopathy , Brittany Urban

Theses/Dissertations from 2019 2019

Intrinsically Disorder Proteins and Liquid-Liquid Phase Transitions in Neurodegenerative Diseases , April Lynn Darling

Genomics and Transcriptomics Approaches to Understanding Drug Resistance Mechanisms in the Malaria Parasite Plasmodium falciparum , Justin Allan Gibbons

Lung Cancer Cells Survive EGFR TKI Exposure Through Upregulation of Cholesterol Synthesis , Mark Howell

Targeting Bacterial Resistance and Cancer Metastasis: A Structure Based Approach , Kyle Galen Kroeck

Design and Delivery of Synthetic mRNA by a Peptide Nanoparticle , John H. Lockhart

Investigating the Role of the Chromosome 19 MicroRNA Cluster in Human Trophoblast Differentiation and Infantile Hemangioma , Ezinne Francess Mong

An Eye Opener in Stroke: Mitochondrial Dysfunction and Stem Cell Repair in Stroke-induced Retinal Ischemia , Hung Vu Thien Nguyen

A Small RNA and DNA Binding Protein Contribute to Biofilm Development in Bartonella henselae , Udoka Okaro

Targeting PTEN for Therapy in Cancer and PTENopathies , Emily Palumbo

Contribution of Retrotransposons to Breast Cancer Malignancy , Isaac D. Raplee

Roux-en-Y Gastric Bypass Attenuates Obesity-Related Liver Injury , Drew Alan Rideout

Evaluation of Novel Hemocompatible Surface Coatings for Extracorporeal Life Support: A Biocompatible Alternative to Systemic Anticoagulation , Teryn Rose Roberts

Theses/Dissertations from 2018 2018

Mechanisms of S1P-Induced Endothelial Barrier Enhancement , Natascha Guimarães Alves

Cyclophilin 40 as a Novel Disaggregase , Jeremy Dustin Baker

Investigating the Role of the RNA Binding Protein LIN28 in the Human Placenta: Implications for Preeclampsia , John Canfield

Proteolysis of CX3CL1 Impacts CX3CR1 Signaling and Therapeutic Benefits in a Tauopathy Model , Dylan John Finneran

Actinomycin D and Telmisartan Combination Therapy Targets Lung Cancer Stem Cells , Ryan Green

Therapeutic modulation of Alzheimer’s disease with biological (HUCBS) and pharmacological (LISPRO) approaches , Md Ahsan Habib

The role of pulmonary stretch receptor afferents in swallow-breathing coordination: a comparison of central respiratory rhythm versus mechanical ventilation on swallow in a decerebrate feline model , Kofi-Kermit A. Horton

Neutrophil Extracellular Traps and Vascular Barrier Injury , Jamie E. Meegan

Targeting the Hsp90/Aha1 Complex for the Treatment of Tauopathies , Lindsey Brooke Shelton

Integrative Signaling of Mitochondria, TRPA1 and TRPV1 in Vagal Neurons , Katherine Stanford

Theses/Dissertations from 2017 2017

Receptor-Associated Protein (RAP) Models In Vivo Reelin Haploinsufficiency: Implications in Schizophrenia , Jamileh Ahmed

The Potential Role of Antiretroviral Efavirenz in HIV Associated Neurocognitive Disorders , Lecia Ashanna Moya Brown

The Role of Elevated Hyaluronan-Mediated Motility Receptor (RHAMM/HMMR) in Ovarian Cancer , Stephanie T. Buttermore

Mass-spectrometry Based Proteomics of Age-related Changes in Murine Microglia , Antwoine Flowers

Astaxanthin Attenuates MPTP Induced Neurotoxicity and Modulates Cognitive Function in Aged Mice , Beth Grimmig

Microfluidic Biopsy Trapping Device for the Real-time Monitoring of the Tumor Microenvironment , Angela Holton

Identifying New Treatment Options and Risk Factors for Type 2 Diabetes: The Potential Role of Thymoquinone and Persistent Organic Pollutants , Shpetim Karandrea

Acetaminophen Associated Neurotoxicity and its Relevance to Neurodevelopmental Disorders , Seol-Hee Kim

Synthesis, in vitro Characterization and Applications of Novel 8-Aminoquinoline Fluorescent Probes , Adonis McQueen

Role of Amylase in Ovarian Cancer , Mai Mohamed

Computational Analysis of Protein Intrinsic Disorder in Human Diseases , Insung Na

Mechanism Elucidation and Inhibitor Discovery against Serine and Metallo-Beta-Lactamases Involved in Bacterial Antibiotic Resistance , Orville A. Pemberton

osteopontin plays a pivotal role in in increasing severity of respiratory syncytial virus infection , Viviana Sampayo-Escobar

Tau-Directed Immunotherapy for Alzheimer’s Disease , Sulana Kay Schroeder

Therapeutic Modulation of Cancer Metabolism with Dichloroacetate and Metformin , Nathan Patrick Ward

Acute Kidney Injury and Chronic Kidney Disease , Jin Wei

Regulation of Extracellular Signal-Regulated Kinase by Histone Deacetylase 6 , Jheng-Yu Wu

Glomerular Hyperfiltration and Hypertension in Diabetes , Jie Zhang

S1P-Mediated Endothelial Barrier Enhancement: Role of Rho Family GTPases and Local Lamellipodia , Xun E. Zhang

Theses/Dissertations from 2016 2016

Antimalarial Exoerythrocytic Stage Drug Discovery and Resistance Studies , Lynn Dong Blake

Respiratory Syncytial Virus-infected Mesenchymal Stem Cells Regulate Immunity via Interferon-beta and Indoleamine-2,3-dioxygenase , Michael B. Cheung

Hypercapnic Hyperoxia Increases Free Radical Production and Cellular Excitability in Rat Caudal Solitary Complex Brain Slice Neurons , Geoffrey Edward Ciarlone

The Effects of Synthetic and Dietary Therapeutics on Learning, Memory, Motor Coordination, and Seizure in an Angelman Syndrome Mouse Model , Stephanie Lynn Ciarlone

Leukemia Inhibitory Factor as a Neuroprotective Agent against Focal Cerebral Ischemia , Stephanie Davis

Intrinsic Disorder Where You Least Expect It: The Incidence and Functional Relevance of Intrinsic Disorder in Enzymes and the Protein Data Bank , Shelly Deforte

Sialylation and Cardiomyocyte Complex N -Glycosylation Protect Against Dilated Cardiomyopathy and Heart Failure , Wei Deng

The Effects of Phytohormones and Isoprenoids in Dihydroartemisinin-induced Dormancy in the Erythrocytic Stages of Plasmodium falciparum , Marvin Duvalsaint Duvalsaint

Antigen Specific Induced T Regulatory Cellular Therapy for Graft-Versus-Host Disease Following Allogeneic Bone Marrow Transplantation , Jessica Lauren Heinrichs

Cardiovascular Effects Evoked by Airway Nociceptive Reflexes in Healthy and Cardiovascular Diseased Rats , Justin Shane Hooper

Contribution of Epithelial Hypoxia Signaling to Pulmonary Fibrosis: Role of FAK1 and Galectin-1 as Driver Molecules , Jaymin J. Kathiriya

Metabolic Therapy for Age-Dependent Impaired Wound Healing , Shannon Lynn Kesl

A Caenorhabditis elegans Model to Detect Developmental Teratogens with Adverse Reproductive and Metabolic Effects , Alexis Ann Killeen

The Concerted Regulation of Intracellular Signaling by Amyloid Precursor Protein and Aβ Peptide , Lisa Kirouac

Significance of PTEN Phosphorylation and its Nuclear Function in Lung Cancer , Prerna Malaney

Targeting Tau Degradation by Small Molecule Inhibitors for Treatment of Tauopathies , Mackenzie Martin

Graphene Quantum Dots-Based Drug Delivery for Ovarian Cancer Therapy , Yiru Qin

Regulation of Palmitoylation Enzymes and Substrates by Intrinsically Disordered Regions , Krishna D. Reddy

Mitochondrial Heteroplasmy Contributes to the Dynamic Atovaquone Resistance Response in Plasmodium falciparum , Sasha Victoria Siegel

Inhibiting the Interaction Between Grp94 and Myocilin to Treat Primary Open-Angle Glaucoma , Andrew Stothert

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Pathology Thesis Topics for MD/DNB

Below is the list of 100 free thesis topics for MD/DNB Pathology. You can select any good Pathology thesis topics for MD/DNB from here. For more thesis topics you can avail the service of premium thesis topics. The premium thesis topics include list of 2000+ Pathology thesis topics as well as recent topics which has been published in various national and international Pathology journals. 

• A Clinical, Endoscopic and Histomorphological evaluation of Esophageal Lesions
• A Clinical, Cytological, Histomorphological evaluation of Lymphnodes in Children
• Histopathological analysis of prostatic lesions and the assessment of prognosis with immunohistochemistry
• A Clinico pathological correlation and analysis of ovarian tumours with study of expression pattern of Pankeratin
• The value of AgNOR study in radiotherapy treated squamous cell carcinoma of the cervix – As a diagnostic and prognostic marker
• A Clinical histomorphological and Immunohistochemical analysis of breast neoplasms
• A Clinical, Endoscopic and Histomorphological Evaluation of Esophageal Lesions
• A Clinical and Histomorphological Analysis of Paediatric Malignant Neoplasms
• Histo Pathological Analysis of Central Nervous System Neoplasms
• Helicobacter pylori related gastritis in adults a clinical, endoscopic
• Fine needle aspiration cytology and histopathological correlation of nodular lesion of thyroid with immunohistochemical study
• Histopathological analysis of prostatic lesions and role of p63 versus high molecular weight cytokeratin in distinguishing prostatin
• Histopathological analysis and p53 expression in intestinal tumors
• Clinicopathological analysis of ovarian tumors and the role of p53 and Ki- 67 in surface epithelial tumors of ovary
• Histopathological analysis and Ki- 67 expression in various central nervous system tumors
• Role of Mucin histochemistry and immunohistochemistry in gastric adenocarcinoma
• Correlation of ER, PR AND HER-2/neu with histological variants of breast carcinoma
• Anaemia in Nonhaematological Malignancies – A Descriptive Study
• Mycotic Lesions in Surgical Pathology
• The role of pap smear in detection of cytological abnormalities of uterine cervix in hiv infected women
• Haematological profile in the differential diagnosis of microcytic hypochromic anaemia in children
• A study of distribution of p53, cyclin d1 and cd44 in oral squamous cell carcinoma
• Histopathological spectrum of ovarian tumors: a descriptive study
• A study of trucut biopsies of hepatic lesions with special reference to immunohistochemistry and special stain
• Study of silver staining of nucleolar organiser regions in malignancies of uterine cervix
• A correlative study on bone marrow angiogenesis with bone marrow fibrosis and spleenomegaly
• Expression of bcl-2 and ki-67 in endometrial lesions
• The expression and diagnostic utility of amacr and 3 in
• Cytological grading of ductal carcinoma of breast in fine needle aspirates and its correlation with histological grading
• Diagnostic utility of squash cytology and its correlation with histopathology in neuropathological specimen
• Placental pathology in low birth weight live births.
• Utility of RBC histograms in various types of anaemia in pediatric age group ( 1 – 18 years).
• Prevalence of anemia in Geriatric population.
• Comparison of digital vs manual assessment of  Ki67 in breast carcinoma patients : A hospital based study.
• Detection of human papilloma virus infection in cases of oral arcinoma using P16 immunohistochemistry.
• The distribution of mast cells in uterine leiomyoma – A hospital based observational study.
• Prevalence of congenital anomalies in fetuses subjected for autopsy – a hospital based cross sectional study.
• Prevalence of thrombocytopenia in pregnancy – A hospital based study.
• Correlation of blood parameters with outcome in covid 19 positive patients.
• Estimating prevalence of SOX – 2 expression in cervical squamous carcinomas – A hospital based cross sectional study.
• Correlation of FNAC and histopathology in the diagnosis of head and neck lesions.
• Assessment of coagulation Parameters in Covid 19 patients – A cross sectional study.
• Hematological and Biochemical Profile of Children below 5 years of age, suspected with hemolytic anemia – A hospital based observational study.
• A Comparative study of hematological and inflammatory markers in preterm labour and term labour.
• A Study of morphological abnormalities in placenta associated with fetal death and still birth – A hospital based observational study.
• Conventional Papanicolou (PAP) stain vs Rehydrated air dried pap stain (RADPS) vs Rapi9d Economical Acetic acid pap stain (REAP) on vaginal smears: An observational study.
• Study of ki67 expression in oral and oropharyngeal Squamous cell carcinoma.
• Comparative study of peripheral smear with RBC indices and RBC histograms incases of anemia in adults.
• Evaluation of CD10 Biomarker Expression in Diagnosis of Colorectal Carcinoma – A One year Cross Sectional Study .
• Evaluation of Derived Indices of Peripheral Whole Blood Cell Counts in Non-Dialysis CKD patients – One year cross sectional study in a tertiary care hospital.
• Histopathological spectrum of upper gastrointestinal tract lesions in patients undergoing upper gastrointestinal endoscoic biopsies.
• Expression of Vimentin as a merker of epithelial – mesenchymal transition in invasive breast carcinoma : A Hospital Based Study.
• Ki67 as a diagnostic indicator in differentiating psoriasis from psoriasiform dermatitits – A hospital based study.
• Study of Dermal Vascular Changes in Psoriasis – An Observational Study.
• Evaluation of Haematological and Biochemical parameters in Chronic Liver Disease patients
• Comparison of the Neutrophil – Lymphocyte, Platelet-Lymphocyte and Monocyte-Lymphocyte ratios in schizophrenic patients with healthy individuals: A cross sectional study.
• Clinical and diagnostic markers in patients with pregnancy induced hypertension- hospital based observational study.
• Diagnostic utility of cell block method versus conventional smear study in pleural & peritoneal fluid cytology
• Evaluation of Role of GATA3 expression in differentiating urothelial carcinomas from adenocarcinomas of prostate.
• The role of p-STAT3 in cervical intra epithelial neoplasia and squamous cell carcinoma.
• Diagnostic utility of TROP – 2 expression in Benign and malignant lesions of thyroid.
• Evaluation of expression of immunohitsochemical (IHC) markers High Molecular weight cytokeratin (HMWCK) and Alpha – methylacyl coA racemose (AMACR) in prostatic needle biopsies and transurethral re-section of prostate (TURP) specimen – a one year observational study.
• Histopathological evaluation to compare the diagnostic accuracy of pipelle’s  endometrial sampling with conventional D & C in patient with AUB.
• Histopathological study and Immunohistochemical expression of EGFR in lung tumours.
• Study of Immunohistochemical expression of AKT (Protein kinase B) in prostatic adenocarcinoma – A descriptive study.
• To study CD64 expression on neutrophil by Flow cytometry as novel biomarker in early diagnosis of  sepsis (as compare to ESR, CRP & Blood culture).
• Ki-67 Expression in endometrial hyperplasia and endometrial carcinoma – an observational study.
• Identification of Lymphatic Invasion in Breast Carcinoma patients using immunomarker D2-40 – A one year cross sectional study in a tertiary care centre of Belagavi.
• Evaluation of Immunohistochemical expression of COX – 2 in breast carcinoma patients – A hospital based study .
• Immunohistochemical expression of   P 16INK4a in patients with squamous cell carcinoma of the cervix – A one year retrospective and prospective study intertiary care hospital.
• To correlate immunohistochemistry of BRCA1 and BRCA2 in breast carcinoma – cross sectional study .
• Expression of Prostate specific membrane antigen in breast cancer patients attending tertiary care hospital – A one year cross sectional study.
• Role of clinicohaematological profile in diagnosis of dengue – One year hospital based observational study .
• Comparision of fluorescent staining and conventional staining of skin biopsy in diagnosis of leprosy – A hospital based study .
• A comparative study to know the haematological profile and Biochemical profile among children with severe acute malnutrition and healthy children .

Disclaimer!

There are many methods of sample size determination. It is one of the first hurdle when someone starts writing a thesis. I have tried to give simplest way of determination of sample size. You need to show the method to your PG teacher before you include this method in your thesis. First confirm from your PG teacher and then only proceed.

Contemporary issues in breast pathology

• Published: 30 March 2022
• Volume 480 , pages 1–3, ( 2022 )

Cite this article

• Cecily Quinn 1 , 2 ,
• Stuart J. Schnitt 3 , 4 &
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This Annual Review Issue highlights contemporary issues in breast pathology. Updated diagnostic criteria for known entities and new tumor entities, as described in the 2019 (5 th Edition) WHO Classification of Breast Tumors, are discussed as are their key clinical features and implications for treatment. Newer therapeutic approaches to breast lesions and new and emerging techniques for evaluation of breast specimens are also addressed.

In their article on Breast carcinomas of low malignant potential , Stuart Schnitt and colleagues discuss the clinical, pathologic, immunophenotypic, and molecular features of selected breast carcinomas with a low risk of metastatic spread to lymph nodes and distant sites. This group includes low-grade adenosquamous carcinoma, fibromatosis-like metaplastic carcinoma, encapsulated papillary carcinoma, solid papillary carcinoma, and tall cell carcinoma with reversed polarity. They emphasize the importance of recognizing and appropriately classifying these tumors to avoid overtreatment of patients.

Luca Cima and colleagues provide new insights into recently established triple negative breast cancer (TNBC) sub-categories with a favorable prognosis. Many of these subtypes share features with salivary gland type carcinomas, including adenoid cystic carcinoma, mucoepidermoid carcinoma, acinic cell carcinoma, secretory carcinoma, and tumors originating from adenomyoepithelial proliferations. The authors provide comprehensive diagnostic criteria with details of specific molecular alterations. They discuss the therapeutic implications of a diagnosis of low-grade TNBC which differ from those applied in the setting of high grade, No Special Type, TNBC.

Carmen van Dooijweert and colleagues review the topic of histological grading in breast cancer with fascinating historical aspects dating back to the 1900s. The authors provide a pragmatic approach to histologic grading by conventional light microscopic evaluation and describe the basics of grading providing didactic H&E sections for different scenarios. The paper addresses prognostic and reproducibility issues, especially in comparison to gene expression profiles, mitotic counts, and Ki67 proliferation index. The value of special stains to better recognize mitotic figures, regular training, and the use of artificial intelligence algorithms in improving grading consistency is emphasized. Gabor Cserni and colleagues provide a historical overview of the introduction of sentinel lymph node biopsy (SLNB) into the clinical management of patients with breast cancer. Their article includes a comprehensive review of the SLNB clinical trials that have informed and changed surgical and pathology practice. The review gives an insight into European National recommendations related to SLNB and differing practices in European pathology departments based on replies to questionnaires from pathologists in 38 countries. It highlights difficulties with SLN assessment and classification of residual nodal disease in the post-neoadjuvant setting and the review examines discordance between TNM and Residual Cancer Burden systems guidance in this context.

The introduction of mammographic screening during the past three decades has led to a major increase in the detection of low-grade ductal carcinoma in situ (DCIS ), potentially resulting in overtreatment of a condition that may not have presented symptomatically or caused harm during the patient's lifetime. Sarah Pinder and colleagues present the morphological features and current knowledge of the natural history and prognosis of this entity. Their article includes a comprehensive review of the low-risk DCIS clinical trials to evaluate active surveillance as an alternative to surgical excision. The authors address the advantages and disadvantages of active surveillance and conclude that to “observe or excise” is neither “a simple question nor an easy one to answer.” Edi Brogi provides a comprehensive review of classic and variant forms of lobular carcinoma in situ (LCIS ) in her article. Helpful hints for distinguishing florid and pleomorphic LCIS from each other and from the classical form of LCIS are provided, and the uses and limitations of E-cadherin, p120 catenin, and beta catenin immunohistochemistry in distinguishing in situ lobular and ductal lesions are clearly discussed and illustrated. The clinical significance of these lesions in core needle biopsy (CNB) and surgical specimens is also discussed.

Melinda Lerwill and colleagues present a detailed overview of fibroepithelial tumors with clear diagnostic criteria to facilitate accurate classification. The review includes morphological descriptions of fibroadenoma variants including cellular, juvenile, myxoid, and complex forms. The difficulties in separating cellular fibroadenoma from benign phyllodes tumor, particularly on CNB specimens, are addressed. The authors review the approach to grading phyllodes tumors, updated according to the recent 2019 WHO classification and contemporary management approaches. The discovery of MED12 mutations in the pathogenesis of fibroepithelial tumors and their potential role in refining diagnosis and prognosis is also discussed. In their article, papillary lesions of the breast , Janina Kulka and colleagues discuss the clinical, radiologic, pathologic, and relevant molecular features of the spectrum of papillary lesions recognized in the 2019 WHO classification. Also discussed are breast lesions characterized by a micropapillary pattern, other differential diagnostic considerations, and challenges encountered in the evaluation of papillary lesions on CNB with emphasis on the role of immunohistochemistry, including myoepithelial cell markers, in diagnosis. In their review, Emad Rakha and colleagues present a practical approach to the assessment of breast spindle cell lesions (SCLs) with emphasis on potential pitfalls and evaluation of CNB specimens. The separation of SCLs into “bland-appearing” and “malignant appearing” rather than benign versus malignant encourages the pathologist to maintain a broad differential diagnosis and to interpret histological findings in clinical context. The review profiles the key features of each entity, including immunohistochemical and molecular characteristics, and includes a series of useful tables.

Cecily Quinn and colleagues review the spectrum of apocrine change in benign, atypical and malignant breast lesions . They address the difficulties in classifying intra-duct apocrine epithelial cell proliferations due to lack of validated criteria and maintaining a balance between not over-interpreting the cytonuclear variation and architectural complexity that may be observed in apocrine metaplasia while recognizing the subtle features of non-high-grade apocrine DCIS. The recently recognized entity of apocrine encapsulated papillary carcinoma is discussed. The review includes a section on invasive apocrine carcinoma with an update on recent advances in our understanding of the genetic landscape of these tumors. Stephen Fox and colleagues provide a comprehensive update on male breast cancer , which is a rare disease, accounting for less than 1% of all breast cancers, although the incidence is rising. The article summarizes important differences and many similarities between female and male breast cancer including androgen receptor positive luminal tumors and hormone receptor clustering with distinct gender-specific prognosis. The article addresses the limited available data derived from multigene-expression tests and future perspectives on mammographic screening in the male population.

The emerging role of tumor infiltrating lymphocytes (TILs) and PD-L1 immunoreactivity in TNBC is summarized by Anne-Vibeke Laenkholm and colleagues with detailed insights into the current prognostic and predictive evidence relating to TILs and PD-L1 scores. It addresses reproducibility in TILs assessment and whether and to what extent different commercially available PD-L1 antibodies are inter-changeable for testing. The authors carefully explain the prognostic information that clinicians can derive from TILs scores and why TILs scores not be used in deciding to de-escalate therapy at this point. The paper analyzes relevant clinical trials, including GeparNuevo, IMPassion 130, and Keynote-173, and explores the interaction between biomarker expression and immunotherapy/chemotherapy benefit in TNBC. Saleh Najjar and Kimberly Allison provide a contemporary review of the recently updated ASCO/CAP guideline for hormone receptor (ER and PR) testing which recognizes ER low positive tumors and the ASCO/CAP HER2 testing guideline update which focuses primarily on less common fluorescence in situ hybridization patterns determined by dual-probe assays (published in 2018). Other biomarkers currently in use, including gene expression profiling assays to assess prognosis and chemotherapy benefit in patients with ER positive cancers and PD-L1 testing to identify patients with TNBC likely to benefit from immune checkpoint inhibitors, are discussed. The role of Ki67 testing in determining the suitability of patients with ER positive breast cancers for treatment with CDK4/6 inhibitors in addition to endocrine therapy and the potential importance of recognizing HER2 low positive cancers to identify patients who may potentially benefit from HER2 antibody–drug conjugates are also discussed.

Important issues related to the emerging role of artificial intelligence are addressed by Mustafa Yousif and colleagues. Rapid advances, due to a combination of the increased use of digital pathology and deep learning neural networks, will potentially have a major impact on the practice of pathology by helping to standardize the diagnosis and classification of breast lesions, evaluate lymph nodes for the presence of metastases, and predict prognosis and response to various forms of therapy. In their article on real time microscopy , Dan Lopez and colleagues take us on a journey into the possible future of breast tissue evaluation. The authors discuss various optical imaging modalities that can be used for evaluating breast tissue in the patient without its removal (“in-vivo microscopy”) and following removal (“ex-vivo microscopy”). Techniques that have already been used to produce images approximating what is seen on stained, formalin-fixed paraffin-embedded histologic sections (albeit of varying quality and resolution) include confocal microscopy, optical coherence tomography, and stereomicroscopy. Other techniques, currently in the research arena, that may have future clinical applications include light sheet microscopy, microscopy with ultraviolet surface excitation, non-linear microscopy, stimulated Raman scattering microscopy, photoacoustic microscopy, and needle micro-endoscopy. The authors speculate on how these optical imaging techniques might be incorporated into future clinical practice.

In our opinion, the selected 15 topics provide a comprehensive and contemporary update on the importance of conventional morphological parameters, current tumor classification, biomarkers and clinical relevance of distinct histological breast cancer subtypes and their precursor lesions, and emerging technologies to evaluate breast specimens. It has been our great privilege to co-edit this 2022 Virchow ’ s Archiv special issue on Contemporary Issues in Breast Pathology.

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Irish National Breast Screening Programme & Histopathology Department, St Vincent’s University Hospital, Dublin, D04 T6F4, Ireland

Cecily Quinn

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Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

Stuart J. Schnitt

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Department of Pathology and Molecular Pathology, University Hospital Zurich, Schmelzbergstrasse 12, 8091, Zurich, CH, Switzerland

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Quinn, C., Schnitt, S.J. & Varga, Z. Contemporary issues in breast pathology. Virchows Arch 480 , 1–3 (2022). https://doi.org/10.1007/s00428-022-03296-6

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DOI : https://doi.org/10.1007/s00428-022-03296-6

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Recent Advances in Pathology: the 2023 Annual Review Issue of The Journal of Pathology

Affiliations.

• 1 Centre for Tumour Biology, Barts Cancer Institute, Queen Mary University of London, London, UK.
• 2 The Pathological Society of Great Britain and Ireland, London, UK.
• 3 Research Center for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, Brno, Czech Republic.
• PMID: 37580852
• DOI: 10.1002/path.6192

The 2023 Annual Review Issue of The Journal of Pathology, Recent Advances in Pathology, contains 12 invited reviews on topics of current interest in pathology. This year, our subjects include immuno-oncology and computational pathology approaches for diagnostic and research applications in human disease. Reviews on the tissue microenvironment include the effects of apoptotic cell-derived exosomes, how understanding the tumour microenvironment predicts prognosis, and the growing appreciation of the diverse functions of fibroblast subtypes in health and disease. We also include up-to-date reviews of modern aspects of the molecular basis of malignancies, and our final review covers new knowledge of vascular and lymphatic regeneration in cardiac disease. All of the reviews contained in this issue are written by expert groups of authors selected to discuss the recent progress in their particular fields and all articles are freely available online (https://pathsocjournals.onlinelibrary.wiley.com/journal/10969896). © 2023 The Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

Keywords: DNA damage repair; VEGF; advanced analytics; apoptosis; artificial intelligence; biomarkers; breast cancer; cancer; cancer-associated fibroblasts; cardiac regeneration; cell cycle arrest; cell plasticity; cellular senescence; clinical trials; computational pathology; copy number alterations; deep learning; digital pathology; endothelial cells; evolution; exosomes; extracellular vesicles; fibroblast heterogeneity; fibrosis; genomic complexity; guidelines; heart failure; histopathology; image analysis; immune checkpoint inhibitors; immunotherapy; immunotherapy failure; keloid scar; lineage tracing; lymphangiogenesis; machine learning; microvesicles; mutations; myocardial infarction; neovascularisation; oncogenic drivers; pancreatic cancer; patient-derived models; pitfalls; prognostic biomarker; quiescence; sarcomagenesis; sarcomas; secondary genetic alterations; senescence escape; senolytics; single cell sequencing; skin; spatial profiling; structural variants; triple-negative breast cancer; tumour heterogeneity; tumour microenvironment; tumour-infiltrating lymphocytes; whole slide images; wound healing.

© 2023 The Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

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