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Research Paper – Structure, Examples and Writing Guide

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Research Paper

Definition:

Research Paper is a written document that presents the author’s original research, analysis, and interpretation of a specific topic or issue.

It is typically based on Empirical Evidence, and may involve qualitative or quantitative research methods, or a combination of both. The purpose of a research paper is to contribute new knowledge or insights to a particular field of study, and to demonstrate the author’s understanding of the existing literature and theories related to the topic.

Structure of Research Paper

The structure of a research paper typically follows a standard format, consisting of several sections that convey specific information about the research study. The following is a detailed explanation of the structure of a research paper:

The title page contains the title of the paper, the name(s) of the author(s), and the affiliation(s) of the author(s). It also includes the date of submission and possibly, the name of the journal or conference where the paper is to be published.

The abstract is a brief summary of the research paper, typically ranging from 100 to 250 words. It should include the research question, the methods used, the key findings, and the implications of the results. The abstract should be written in a concise and clear manner to allow readers to quickly grasp the essence of the research.

Introduction

The introduction section of a research paper provides background information about the research problem, the research question, and the research objectives. It also outlines the significance of the research, the research gap that it aims to fill, and the approach taken to address the research question. Finally, the introduction section ends with a clear statement of the research hypothesis or research question.

Literature Review

The literature review section of a research paper provides an overview of the existing literature on the topic of study. It includes a critical analysis and synthesis of the literature, highlighting the key concepts, themes, and debates. The literature review should also demonstrate the research gap and how the current study seeks to address it.

The methods section of a research paper describes the research design, the sample selection, the data collection and analysis procedures, and the statistical methods used to analyze the data. This section should provide sufficient detail for other researchers to replicate the study.

The results section presents the findings of the research, using tables, graphs, and figures to illustrate the data. The findings should be presented in a clear and concise manner, with reference to the research question and hypothesis.

The discussion section of a research paper interprets the findings and discusses their implications for the research question, the literature review, and the field of study. It should also address the limitations of the study and suggest future research directions.

The conclusion section summarizes the main findings of the study, restates the research question and hypothesis, and provides a final reflection on the significance of the research.

The references section provides a list of all the sources cited in the paper, following a specific citation style such as APA, MLA or Chicago.

How to Write Research Paper

You can write Research Paper by the following guide:

• Choose a Topic: The first step is to select a topic that interests you and is relevant to your field of study. Brainstorm ideas and narrow down to a research question that is specific and researchable.
• Conduct a Literature Review: The literature review helps you identify the gap in the existing research and provides a basis for your research question. It also helps you to develop a theoretical framework and research hypothesis.
• Develop a Thesis Statement : The thesis statement is the main argument of your research paper. It should be clear, concise and specific to your research question.
• Plan your Research: Develop a research plan that outlines the methods, data sources, and data analysis procedures. This will help you to collect and analyze data effectively.
• Collect and Analyze Data: Collect data using various methods such as surveys, interviews, observations, or experiments. Analyze data using statistical tools or other qualitative methods.
• Organize your Paper : Organize your paper into sections such as Introduction, Literature Review, Methods, Results, Discussion, and Conclusion. Ensure that each section is coherent and follows a logical flow.
• Write your Paper : Start by writing the introduction, followed by the literature review, methods, results, discussion, and conclusion. Ensure that your writing is clear, concise, and follows the required formatting and citation styles.
• Edit and Proofread your Paper: Review your paper for grammar and spelling errors, and ensure that it is well-structured and easy to read. Ask someone else to review your paper to get feedback and suggestions for improvement.
• Cite your Sources: Ensure that you properly cite all sources used in your research paper. This is essential for giving credit to the original authors and avoiding plagiarism.

Research Paper Example

Note : The below example research paper is for illustrative purposes only and is not an actual research paper. Actual research papers may have different structures, contents, and formats depending on the field of study, research question, data collection and analysis methods, and other factors. Students should always consult with their professors or supervisors for specific guidelines and expectations for their research papers.

Research Paper Example sample for Students:

Title: The Impact of Social Media on Mental Health among Young Adults

Abstract: This study aims to investigate the impact of social media use on the mental health of young adults. A literature review was conducted to examine the existing research on the topic. A survey was then administered to 200 university students to collect data on their social media use, mental health status, and perceived impact of social media on their mental health. The results showed that social media use is positively associated with depression, anxiety, and stress. The study also found that social comparison, cyberbullying, and FOMO (Fear of Missing Out) are significant predictors of mental health problems among young adults.

Introduction: Social media has become an integral part of modern life, particularly among young adults. While social media has many benefits, including increased communication and social connectivity, it has also been associated with negative outcomes, such as addiction, cyberbullying, and mental health problems. This study aims to investigate the impact of social media use on the mental health of young adults.

Literature Review: The literature review highlights the existing research on the impact of social media use on mental health. The review shows that social media use is associated with depression, anxiety, stress, and other mental health problems. The review also identifies the factors that contribute to the negative impact of social media, including social comparison, cyberbullying, and FOMO.

Methods : A survey was administered to 200 university students to collect data on their social media use, mental health status, and perceived impact of social media on their mental health. The survey included questions on social media use, mental health status (measured using the DASS-21), and perceived impact of social media on their mental health. Data were analyzed using descriptive statistics and regression analysis.

Results : The results showed that social media use is positively associated with depression, anxiety, and stress. The study also found that social comparison, cyberbullying, and FOMO are significant predictors of mental health problems among young adults.

Discussion : The study’s findings suggest that social media use has a negative impact on the mental health of young adults. The study highlights the need for interventions that address the factors contributing to the negative impact of social media, such as social comparison, cyberbullying, and FOMO.

Conclusion : In conclusion, social media use has a significant impact on the mental health of young adults. The study’s findings underscore the need for interventions that promote healthy social media use and address the negative outcomes associated with social media use. Future research can explore the effectiveness of interventions aimed at reducing the negative impact of social media on mental health. Additionally, longitudinal studies can investigate the long-term effects of social media use on mental health.

Limitations : The study has some limitations, including the use of self-report measures and a cross-sectional design. The use of self-report measures may result in biased responses, and a cross-sectional design limits the ability to establish causality.

Implications: The study’s findings have implications for mental health professionals, educators, and policymakers. Mental health professionals can use the findings to develop interventions that address the negative impact of social media use on mental health. Educators can incorporate social media literacy into their curriculum to promote healthy social media use among young adults. Policymakers can use the findings to develop policies that protect young adults from the negative outcomes associated with social media use.

References :

• Twenge, J. M., & Campbell, W. K. (2019). Associations between screen time and lower psychological well-being among children and adolescents: Evidence from a population-based study. Preventive medicine reports, 15, 100918.
• Primack, B. A., Shensa, A., Escobar-Viera, C. G., Barrett, E. L., Sidani, J. E., Colditz, J. B., … & James, A. E. (2017). Use of multiple social media platforms and symptoms of depression and anxiety: A nationally-representative study among US young adults. Computers in Human Behavior, 69, 1-9.
• Van der Meer, T. G., & Verhoeven, J. W. (2017). Social media and its impact on academic performance of students. Journal of Information Technology Education: Research, 16, 383-398.

Appendix : The survey used in this study is provided below.

Social Media and Mental Health Survey

• How often do you use social media per day?
• Less than 30 minutes
• 30 minutes to 1 hour
• 1 to 2 hours
• 2 to 4 hours
• More than 4 hours
• Which social media platforms do you use?
• Others (Please specify)
• How often do you experience the following on social media?
• Social comparison (comparing yourself to others)
• Cyberbullying
• Fear of Missing Out (FOMO)
• Have you ever experienced any of the following mental health problems in the past month?
• Do you think social media use has a positive or negative impact on your mental health?
• Very positive
• Somewhat positive
• Somewhat negative
• Very negative
• In your opinion, which factors contribute to the negative impact of social media on mental health?
• Social comparison
• In your opinion, what interventions could be effective in reducing the negative impact of social media on mental health?
• Education on healthy social media use
• Counseling for mental health problems caused by social media
• Social media detox programs
• Regulation of social media use

Thank you for your participation!

Applications of Research Paper

Research papers have several applications in various fields, including:

• Advancing knowledge: Research papers contribute to the advancement of knowledge by generating new insights, theories, and findings that can inform future research and practice. They help to answer important questions, clarify existing knowledge, and identify areas that require further investigation.
• Informing policy: Research papers can inform policy decisions by providing evidence-based recommendations for policymakers. They can help to identify gaps in current policies, evaluate the effectiveness of interventions, and inform the development of new policies and regulations.
• Improving practice: Research papers can improve practice by providing evidence-based guidance for professionals in various fields, including medicine, education, business, and psychology. They can inform the development of best practices, guidelines, and standards of care that can improve outcomes for individuals and organizations.
• Educating students : Research papers are often used as teaching tools in universities and colleges to educate students about research methods, data analysis, and academic writing. They help students to develop critical thinking skills, research skills, and communication skills that are essential for success in many careers.
• Fostering collaboration: Research papers can foster collaboration among researchers, practitioners, and policymakers by providing a platform for sharing knowledge and ideas. They can facilitate interdisciplinary collaborations and partnerships that can lead to innovative solutions to complex problems.

When to Write Research Paper

Research papers are typically written when a person has completed a research project or when they have conducted a study and have obtained data or findings that they want to share with the academic or professional community. Research papers are usually written in academic settings, such as universities, but they can also be written in professional settings, such as research organizations, government agencies, or private companies.

Here are some common situations where a person might need to write a research paper:

• For academic purposes: Students in universities and colleges are often required to write research papers as part of their coursework, particularly in the social sciences, natural sciences, and humanities. Writing research papers helps students to develop research skills, critical thinking skills, and academic writing skills.
• For publication: Researchers often write research papers to publish their findings in academic journals or to present their work at academic conferences. Publishing research papers is an important way to disseminate research findings to the academic community and to establish oneself as an expert in a particular field.
• To inform policy or practice : Researchers may write research papers to inform policy decisions or to improve practice in various fields. Research findings can be used to inform the development of policies, guidelines, and best practices that can improve outcomes for individuals and organizations.
• To share new insights or ideas: Researchers may write research papers to share new insights or ideas with the academic or professional community. They may present new theories, propose new research methods, or challenge existing paradigms in their field.

Purpose of Research Paper

The purpose of a research paper is to present the results of a study or investigation in a clear, concise, and structured manner. Research papers are written to communicate new knowledge, ideas, or findings to a specific audience, such as researchers, scholars, practitioners, or policymakers. The primary purposes of a research paper are:

• To contribute to the body of knowledge : Research papers aim to add new knowledge or insights to a particular field or discipline. They do this by reporting the results of empirical studies, reviewing and synthesizing existing literature, proposing new theories, or providing new perspectives on a topic.
• To inform or persuade: Research papers are written to inform or persuade the reader about a particular issue, topic, or phenomenon. They present evidence and arguments to support their claims and seek to persuade the reader of the validity of their findings or recommendations.
• To advance the field: Research papers seek to advance the field or discipline by identifying gaps in knowledge, proposing new research questions or approaches, or challenging existing assumptions or paradigms. They aim to contribute to ongoing debates and discussions within a field and to stimulate further research and inquiry.
• To demonstrate research skills: Research papers demonstrate the author’s research skills, including their ability to design and conduct a study, collect and analyze data, and interpret and communicate findings. They also demonstrate the author’s ability to critically evaluate existing literature, synthesize information from multiple sources, and write in a clear and structured manner.

Characteristics of Research Paper

Research papers have several characteristics that distinguish them from other forms of academic or professional writing. Here are some common characteristics of research papers:

• Evidence-based: Research papers are based on empirical evidence, which is collected through rigorous research methods such as experiments, surveys, observations, or interviews. They rely on objective data and facts to support their claims and conclusions.
• Structured and organized: Research papers have a clear and logical structure, with sections such as introduction, literature review, methods, results, discussion, and conclusion. They are organized in a way that helps the reader to follow the argument and understand the findings.
• Formal and objective: Research papers are written in a formal and objective tone, with an emphasis on clarity, precision, and accuracy. They avoid subjective language or personal opinions and instead rely on objective data and analysis to support their arguments.
• Citations and references: Research papers include citations and references to acknowledge the sources of information and ideas used in the paper. They use a specific citation style, such as APA, MLA, or Chicago, to ensure consistency and accuracy.
• Peer-reviewed: Research papers are often peer-reviewed, which means they are evaluated by other experts in the field before they are published. Peer-review ensures that the research is of high quality, meets ethical standards, and contributes to the advancement of knowledge in the field.
• Objective and unbiased: Research papers strive to be objective and unbiased in their presentation of the findings. They avoid personal biases or preconceptions and instead rely on the data and analysis to draw conclusions.

Advantages of Research Paper

Research papers have many advantages, both for the individual researcher and for the broader academic and professional community. Here are some advantages of research papers:

• Contribution to knowledge: Research papers contribute to the body of knowledge in a particular field or discipline. They add new information, insights, and perspectives to existing literature and help advance the understanding of a particular phenomenon or issue.
• Opportunity for intellectual growth: Research papers provide an opportunity for intellectual growth for the researcher. They require critical thinking, problem-solving, and creativity, which can help develop the researcher’s skills and knowledge.
• Career advancement: Research papers can help advance the researcher’s career by demonstrating their expertise and contributions to the field. They can also lead to new research opportunities, collaborations, and funding.
• Academic recognition: Research papers can lead to academic recognition in the form of awards, grants, or invitations to speak at conferences or events. They can also contribute to the researcher’s reputation and standing in the field.
• Impact on policy and practice: Research papers can have a significant impact on policy and practice. They can inform policy decisions, guide practice, and lead to changes in laws, regulations, or procedures.
• Advancement of society: Research papers can contribute to the advancement of society by addressing important issues, identifying solutions to problems, and promoting social justice and equality.

Limitations of Research Paper

Research papers also have some limitations that should be considered when interpreting their findings or implications. Here are some common limitations of research papers:

• Limited generalizability: Research findings may not be generalizable to other populations, settings, or contexts. Studies often use specific samples or conditions that may not reflect the broader population or real-world situations.
• Potential for bias : Research papers may be biased due to factors such as sample selection, measurement errors, or researcher biases. It is important to evaluate the quality of the research design and methods used to ensure that the findings are valid and reliable.
• Ethical concerns: Research papers may raise ethical concerns, such as the use of vulnerable populations or invasive procedures. Researchers must adhere to ethical guidelines and obtain informed consent from participants to ensure that the research is conducted in a responsible and respectful manner.
• Limitations of methodology: Research papers may be limited by the methodology used to collect and analyze data. For example, certain research methods may not capture the complexity or nuance of a particular phenomenon, or may not be appropriate for certain research questions.
• Publication bias: Research papers may be subject to publication bias, where positive or significant findings are more likely to be published than negative or non-significant findings. This can skew the overall findings of a particular area of research.
• Time and resource constraints: Research papers may be limited by time and resource constraints, which can affect the quality and scope of the research. Researchers may not have access to certain data or resources, or may be unable to conduct long-term studies due to practical limitations.

About the author

Muhammad Hassan

Researcher, Academic Writer, Web developer

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The Ultimate Guide to Writing and Publishing Scientific Papers

A white page, and a blinking cursor: How can a blank document be so intimidating? You might hear the voice of your Ph.D. professor rumbling in your head: “Well done with the research, why don’t you put all that data together in a scientific paper so we can get it published?”

Well, it’s more challenging than it sounds!

For first-time authors, the chances of writing their own scientific research may both be overwhelming and exciting. Encountered with a mountain of notes, data, remnants of the research process, and days spent doing experiments, it may be daunting to figure out where and how to begin the process of writing a scientific paper!

The good news is, you don’t have to be a talented writer to pen-down a good scientific paper, but just have to be an organized and careful writer.

This is why we have put time and effort into creating an exceptional guide on how to write a scientific paper that will help you present your research successfully to your supervisors or publications without any clutter!

Before we begin, let’s learn about the touchstones or benchmarks of scientific writing for authors!

What is a Scientific Paper? (Definition)

A scientific paper is a manuscript that represents an original work of scientific research or study. It can be an addition to the ongoing study in a field, can be groundbreaking, or a comparative study between different approaches.

Most times, a scientific paper draws the research performed by an individual or a group of people. These papers showcase valuable analysis in fields like theoretical physics, mathematics, etc., and are routinely published in scientific journals.

Read more: The Ultimate Guide on Technical Documentation

3 Golden Rules of Scientific Writing

According to a study by lijunsun, scientists and writers have identified difficulties in communicating science to the public through typical scientific prose.

Simply put, it is important for researchers to maintain a balance between receiving respect and recognition for their research in a particular field and making sure that their work is understandable to a wider audience. The latter can be achieved through clarity, simplicity, and accuracy.

Clarity – Research is unambiguous and free of irrelevant conjecture or detail.

Simplicity – Language, sentence, and paragraph structure are easy to comprehend and follow without losing scientific credibility or authority.

Accuracy – Data, figures, tables, references, and citations are illustrated verifiably and honestly.

Why are Scientific Papers Important?

A scientific paper is both a testing device and a teaching device.

When handled correctly, it empowers you to

• Learn and read an assignment carefully,
• Research the nuances of your topic,
• Refine your focus to a strong,
• Offer arguable thesis,
• Select the best evidence to prove the analysis of your dissertation.

As a primary teaching device, the scientific paper in your field trains you to self-learn some rules and expectations in terms of:

• Writing format,
• Appropriateness of language and content,
• Submission requirements,
• Bibliographic styles, and much more.

As you move onward with your research, you’ll find that the scientific paper quickly becomes the educational “ coin of the realm .” Hence, it’s important to approach any scientific paper with zeal for higher learning.

Read more:  Technical Report: What is it & How to Write it? (Steps & Structure Included)

How to Write a Scientific Paper? (Steps & Format)

When you begin with writing your scientific manuscript, the first thing to consider is the format and order of sections in relation to your research or the information you want to showcase.

A scientific paper follows the  conventional format of research-based writing, which provides a deeper understanding of the purpose of each section. The structure starts with:

Step 1. Add Title in the Paper

A title should be of the fewest words possible, accurately describing the content of the paper. Try to eliminate unnecessary words such as “Investigations of …”, “A study of …”, “Observations on …”, etc.

An improperly titled scientific paper might never reach the readers for which it was intended. Hence, mention the name of the study, a particular region it was conducted in, or an element it contains in the title.

Step 2. Mention Keywords List

A keyword list offers the opportunity to add keywords, in addition to those already written in the title. Optimal use of keywords may increase the chances of interested parties to easily locate your scientific paper.

Step 3.  Add Abstract

A well-defined abstract allows the reader to identify the basic content of your paper quickly and accurately, to determine its relevance, and decide whether to read it in its entirety. The abstract briefly states the principal, scope, and objectives of the research. The abstract typically should not exceed 250 words. If you can convey the important details of the paper in 100 words, do not try to use more.

Step 4. Start with  Introduction

An introduction begins by introducing the authors and their relevant fields to the reader. A common mistake made is introducing their areas of study while not mentioning their major findings in descriptive scientific writing, enabling the reader to place the current work in context.

The ending of the introduction can be done through a statement of objectives or, with a brief statement of the principal findings. Either way, the reader must have an idea of where the paper is headed to process the development of the evidence.

Step 5. Mention Scientific  Materials and Methods Used

The primary purpose of the ‘Materials and Methods’ section is to provide enough detail for a competent worker to replicate your research and reproduce the results.

The scientific method requires your results to be reproducible, and provide a basis for the reiteration of the study by others. However, if case your material and method have been previously published in a journal, only the name of the study and a literature reference is needed.

Step 6. Write down  Results

Results display your findings, figures, and tables of your study. It represents the data, condensed, and digested with important trends that are extracted while researching. Since the results hold new knowledge that you are contributing to the world, it is important that your data is simply and clearly stated.

Step 7. Create a  Discussion Section

A discussion involves talking and answering about different aspects of the scientific paper such as: what principles have been established or reinforced; how your findings compare to the findings of others, what generalizations can be drawn, and whether there are any practical/theoretical implications of your research.

Step 8. Mention References

A list of references presented alphabetically by author’s surname, or number, based on the publication, must be provided at the end of your scientific paper. The reference list must contain all references cited in the text. Include author details such as the title of the article, year of publication, name of journal or book or volume, and page numbers with each reference

Now that you know the key elements to include in your scientific paper, it’s time to introduce you to an awesome tool that will make writing a scientific paper, a breeze!

Ditch Your Boring, Old Editor, and Write a Scientific Paper the Smart Way with Bit.ai

Bit.ai is a new-age documentation and knowledge management tool that allows researchers and teams to collaborate, share, track, and manage all knowledge and research in one place. Bit documents, unlike your standard Word Docs or Google Docs, are interactive .  This means that authors can use Bit to create interactive, media-rich scientific papers easily!

Thus, Bit brings together everything you need to conduct and write a comprehensive scientific paper under one roof, cutting down your efforts in half! Bit has a super easy and fun interface, making onboarding new users easier than ever!

All-in-all Bit is like Google Docs on steroids ! So, no more settling for those boring text editors when you have an excessively robust solution to walk you through!

• Organized workspaces and folders – Bit brings all your research in one place by allowing you to organize information in workspaces and folders. Workspaces can be created around projects, studies, departments, and fields. Everyone added to a workspace can access and collaborate on its content. Inside each workspace, you can create an unlimited number of wikis and access your content library.
• Content library –  Bit has a content library at the workspace level where you can store and share assets. You can save images, files, and content easily and can access it at any point.
• Rich embed options – Bit.ai integrates with over 100+ web applications (Ex: YouTube, PDFs, LucidChart, Google Drive, etc.) to help you weave information in their wikis beyond just text and images.
• Smart search – Bit has very robust search functionality that allows anyone to find information quickly. You can search for folders, files, documents, and content inside your documents across all of your workspaces.
• Interlink documents – Bit allows authors to create unlimited documents and interlink them to create wikis that expand the knowledge base. Simply highlight the words and you have the option to create a new document.
• Permission & sharing access – Bit supports features like document tracking, cloud upload, templates, document locking, document expiration, password protection, etc.

Our team at  bit.ai  has created a few awesome templates to make your research process more efficient. Make sure to check them out before you go, y our team might need them!

• Case Study Template
• Research Paper Template
• Competitor Research Template
• Brainstorming Template
• SWOT Analysis Template
• White Paper Template

Read More:  How Bit.ai Can Help You Manage Your Academic Research?

Over to You!

Scientific papers are the medium through which scientists report their work to the world. Their professional reputation is based on how these papers are acknowledged by the scientific community.

No matter how great the actual experiment is, a poorly written scientific paper may negatively affect one’s professional honor, or worse, prevent the paper from being published at all. Therefore, it is extremely crucial to learn everything about writing a scientific paper.

There is no better tool than Bit to help you save time and energy required for the whole writing process. It’s time to make a mark in the scientific community by showcasing a well-crafted scientific paper with Bit. If you want any further assistance in presenting your research, let us know by tweeting us @bit_docs. Cheers!

Further reads:

How To Write A Research Paper?

Thesis Statement: Definition, Importance, Steps & Tips!

How To Write A Case Study (With Template)

How to Write an Insane White Paper that Gets High Engagement?

Mastering Request for Proposals (RFP): A Step-by-Step Guide

9 Essential Writing Tips Every Writer Must Use!

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About Bit.ai

Bit.ai is the essential next-gen workplace and document collaboration platform. that helps teams share knowledge by connecting any type of digital content. With this intuitive, cloud-based solution, anyone can work visually and collaborate in real-time while creating internal notes, team projects, knowledge bases, client-facing content, and more.

The smartest online Google Docs and Word alternative, Bit.ai is used in over 100 countries by professionals everywhere, from IT teams creating internal documentation and knowledge bases, to sales and marketing teams sharing client materials and client portals.

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• Research Guides

BSCI 1510L Literature and Stats Guide: 1 What is a scientific paper?

1 what is a scientific paper.

• 2 Referencing and accessing papers
• 2.1 Literature Cited
• 2.2 Accessing Scientific Papers
• 2.3 Traversing the web of citations
• 2.4 Keyword Searches
• 3 Style of scientific writing
• 3.1 Specific details regarding scientific writing
• 3.2 Components of a scientific paper
• 4 Summary of the Writing Guide and Further Information
• Appendix A: Calculation Final Concentrations
• 1 Formulas in Excel
• 2 Basic operations in Excel
• 3 Measurement and Variation
• 3.1 Describing Quantities and Their Variation
• 3.2 Samples Versus Populations
• 3.3 Calculating Descriptive Statistics using Excel
• 4 Variation and differences
• 5 Differences in Experimental Science
• 5.1 Aside: Commuting to Nashville
• 5.2 P and Detecting Differences in Variable Quantities
• 5.3 Statistical significance
• 5.4 A test for differences of sample means: 95% Confidence Intervals
• 5.5 Error bars in figures
• 5.6 Discussing statistics in your scientific writing
• 6 Scatter plot, trendline, and linear regression
• 7 The t-test of Means
• 8 Paired t-test
• 9 Two-Tailed and One-Tailed Tests
• 10 Variation on t-tests: ANOVA
• 11 Reporting the Results of a Statistical Test
• 12 Summary of statistical tests
• 1 Objectives
• 2 Project timeline
• 3 Background
• 4 Previous work in the BSCI 111 class
• 5 General notes about the project
• 6 About the paper
• 7 References

Scientific papers (also known as a "journal articles") are a special type of written work that have particular characteristics:

• They are usually published in a periodical called a journal whose purpose is to publish this kind of work.  Generally, journals differ greatly from general interest writing on scientific topics such as magazine articles and science news (e.g. those in National Geographic, Scientific American, Discover, etc.) although some journals also have a section devoted to general interest writing.  Occasionally scientific papers are compiled in book form but this is not the norm.
• They are peer reviewed .  That means that the paper has been subjected to the scrutiny of several experts in the field who verify the quality of the writing and the accuracy of the analysis and conclusions drawn by the authors. 
• They are citable .  This means that: the content is stable, the journal is readily available in libraries and (usually) through the Web, and there are standardized methods of identifying a particular article.  Thus an author can refer to a paper with confidence that a reader can easily look up that reference at any point in the future.
• They include citations .  This means that the paper frequently makes reference to previous publications that are relevant to the work being discussed.  All cited works are listed in a reference section at the end of the paper.  Footnotes at the bottom of each pager are not used to make citations. 
• Introduction
• References/Literature cited
• They follow a standardized style of writing and data presentation.
• Over the next four weeks of lab, you will be examining some published work on a topic.  We will analyze parts of these papers each week, such as examining the results between the papers. After that, you will be given a sample paper to critique/revise.  By Mid-semester, you will have seen enough of "how to write" in science and will write your own formal journal-style paper.  There are quite a few details to learn but they are NOT challenging and are no different in complexity than when you learned the rules to reading and writing.   Thus, you should really pay attention to these details early on and not have to worry about cramming them in all at once later on.
• << Previous: Scientific Literature Guide
• Next: 2 Referencing and accessing papers >>
• Last Updated: Jul 30, 2024 9:53 AM
• URL: https://researchguides.library.vanderbilt.edu/bsci1510L

How To Write A Research Paper

Step-By-Step Tutorial With Examples + FREE Template

By: Derek Jansen (MBA) | Expert Reviewer: Dr Eunice Rautenbach | March 2024

For many students, crafting a strong research paper from scratch can feel like a daunting task – and rightly so! In this post, we’ll unpack what a research paper is, what it needs to do , and how to write one – in three easy steps. 🙂 

Overview: Writing A Research Paper

What (exactly) is a research paper.

• How to write a research paper
• Stage 1 : Topic & literature search
• Stage 2 : Structure & outline
• Stage 3 : Iterative writing
• Key takeaways

Let’s start by asking the most important question, “ What is a research paper? ”.

Simply put, a research paper is a scholarly written work where the writer (that’s you!) answers a specific question (this is called a research question ) through evidence-based arguments . Evidence-based is the keyword here. In other words, a research paper is different from an essay or other writing assignments that draw from the writer’s personal opinions or experiences. With a research paper, it’s all about building your arguments based on evidence (we’ll talk more about that evidence a little later).

Now, it’s worth noting that there are many different types of research papers , including analytical papers (the type I just described), argumentative papers, and interpretative papers. Here, we’ll focus on analytical papers , as these are some of the most common – but if you’re keen to learn about other types of research papers, be sure to check out the rest of the blog .

With that basic foundation laid, let’s get down to business and look at how to write a research paper .

Overview: The 3-Stage Process

While there are, of course, many potential approaches you can take to write a research paper, there are typically three stages to the writing process. So, in this tutorial, we’ll present a straightforward three-step process that we use when working with students at Grad Coach.

These three steps are:

• Finding a research topic and reviewing the existing literature
• Developing a provisional structure and outline for your paper, and
• Writing up your initial draft and then refining it iteratively

Let’s dig into each of these.

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Step 1: Find a topic and review the literature

As we mentioned earlier, in a research paper, you, as the researcher, will try to answer a question . More specifically, that’s called a research question , and it sets the direction of your entire paper. What’s important to understand though is that you’ll need to answer that research question with the help of high-quality sources – for example, journal articles, government reports, case studies, and so on. We’ll circle back to this in a minute.

The first stage of the research process is deciding on what your research question will be and then reviewing the existing literature (in other words, past studies and papers) to see what they say about that specific research question. In some cases, your professor may provide you with a predetermined research question (or set of questions). However, in many cases, you’ll need to find your own research question within a certain topic area.

Finding a strong research question hinges on identifying a meaningful research gap – in other words, an area that’s lacking in existing research. There’s a lot to unpack here, so if you wanna learn more, check out the plain-language explainer video below.

Once you’ve figured out which question (or questions) you’ll attempt to answer in your research paper, you’ll need to do a deep dive into the existing literature – this is called a “ literature search ”. Again, there are many ways to go about this, but your most likely starting point will be Google Scholar .

If you’re new to Google Scholar, think of it as Google for the academic world. You can start by simply entering a few different keywords that are relevant to your research question and it will then present a host of articles for you to review. What you want to pay close attention to here is the number of citations for each paper – the more citations a paper has, the more credible it is (generally speaking – there are some exceptions, of course).

Ideally, what you’re looking for are well-cited papers that are highly relevant to your topic. That said, keep in mind that citations are a cumulative metric , so older papers will often have more citations than newer papers – just because they’ve been around for longer. So, don’t fixate on this metric in isolation – relevance and recency are also very important.

Beyond Google Scholar, you’ll also definitely want to check out academic databases and aggregators such as Science Direct, PubMed, JStor and so on. These will often overlap with the results that you find in Google Scholar, but they can also reveal some hidden gems – so, be sure to check them out.

Once you’ve worked your way through all the literature, you’ll want to catalogue all this information in some sort of spreadsheet so that you can easily recall who said what, when and within what context. If you’d like, we’ve got a free literature spreadsheet that helps you do exactly that.

Step 2: Develop a structure and outline

With your research question pinned down and your literature digested and catalogued, it’s time to move on to planning your actual research paper .

It might sound obvious, but it’s really important to have some sort of rough outline in place before you start writing your paper. So often, we see students eagerly rushing into the writing phase, only to land up with a disjointed research paper that rambles on in multiple

Now, the secret here is to not get caught up in the fine details . Realistically, all you need at this stage is a bullet-point list that describes (in broad strokes) what you’ll discuss and in what order. It’s also useful to remember that you’re not glued to this outline – in all likelihood, you’ll chop and change some sections once you start writing, and that’s perfectly okay. What’s important is that you have some sort of roadmap in place from the start.

At this stage you might be wondering, “ But how should I structure my research paper? ”. Well, there’s no one-size-fits-all solution here, but in general, a research paper will consist of a few relatively standardised components:

• Introduction
• Literature review
• Methodology

Let’s take a look at each of these.

First up is the introduction section . As the name suggests, the purpose of the introduction is to set the scene for your research paper. There are usually (at least) four ingredients that go into this section – these are the background to the topic, the research problem and resultant research question , and the justification or rationale. If you’re interested, the video below unpacks the introduction section in more detail. 

The next section of your research paper will typically be your literature review . Remember all that literature you worked through earlier? Well, this is where you’ll present your interpretation of all that content . You’ll do this by writing about recent trends, developments, and arguments within the literature – but more specifically, those that are relevant to your research question . The literature review can oftentimes seem a little daunting, even to seasoned researchers, so be sure to check out our extensive collection of literature review content here .

With the introduction and lit review out of the way, the next section of your paper is the research methodology . In a nutshell, the methodology section should describe to your reader what you did (beyond just reviewing the existing literature) to answer your research question. For example, what data did you collect, how did you collect that data, how did you analyse that data and so on? For each choice, you’ll also need to justify why you chose to do it that way, and what the strengths and weaknesses of your approach were.

Now, it’s worth mentioning that for some research papers, this aspect of the project may be a lot simpler . For example, you may only need to draw on secondary sources (in other words, existing data sets). In some cases, you may just be asked to draw your conclusions from the literature search itself (in other words, there may be no data analysis at all). But, if you are required to collect and analyse data, you’ll need to pay a lot of attention to the methodology section. The video below provides an example of what the methodology section might look like.

By this stage of your paper, you will have explained what your research question is, what the existing literature has to say about that question, and how you analysed additional data to try to answer your question. So, the natural next step is to present your analysis of that data . This section is usually called the “results” or “analysis” section and this is where you’ll showcase your findings.

Depending on your school’s requirements, you may need to present and interpret the data in one section – or you might split the presentation and the interpretation into two sections. In the latter case, your “results” section will just describe the data, and the “discussion” is where you’ll interpret that data and explicitly link your analysis back to your research question. If you’re not sure which approach to take, check in with your professor or take a look at past papers to see what the norms are for your programme.

Alright – once you’ve presented and discussed your results, it’s time to wrap it up . This usually takes the form of the “ conclusion ” section. In the conclusion, you’ll need to highlight the key takeaways from your study and close the loop by explicitly answering your research question. Again, the exact requirements here will vary depending on your programme (and you may not even need a conclusion section at all) – so be sure to check with your professor if you’re unsure.

Step 3: Write and refine

Finally, it’s time to get writing. All too often though, students hit a brick wall right about here… So, how do you avoid this happening to you?

Well, there’s a lot to be said when it comes to writing a research paper (or any sort of academic piece), but we’ll share three practical tips to help you get started.

First and foremost , it’s essential to approach your writing as an iterative process. In other words, you need to start with a really messy first draft and then polish it over multiple rounds of editing. Don’t waste your time trying to write a perfect research paper in one go. Instead, take the pressure off yourself by adopting an iterative approach.

Secondly , it’s important to always lean towards critical writing , rather than descriptive writing. What does this mean? Well, at the simplest level, descriptive writing focuses on the “ what ”, while critical writing digs into the “ so what ” – in other words, the implications . If you’re not familiar with these two types of writing, don’t worry! You can find a plain-language explanation here.

Last but not least, you’ll need to get your referencing right. Specifically, you’ll need to provide credible, correctly formatted citations for the statements you make. We see students making referencing mistakes all the time and it costs them dearly. The good news is that you can easily avoid this by using a simple reference manager . If you don’t have one, check out our video about Mendeley, an easy (and free) reference management tool that you can start using today.

Recap: Key Takeaways

We’ve covered a lot of ground here. To recap, the three steps to writing a high-quality research paper are:

• To choose a research question and review the literature
• To plan your paper structure and draft an outline
• To take an iterative approach to writing, focusing on critical writing and strong referencing

Remember, this is just a b ig-picture overview of the research paper development process and there’s a lot more nuance to unpack. So, be sure to grab a copy of our free research paper template to learn more about how to write a research paper.

Can you help me with a full paper template for this Abstract:

Background: Energy and sports drinks have gained popularity among diverse demographic groups, including adolescents, athletes, workers, and college students. While often used interchangeably, these beverages serve distinct purposes, with energy drinks aiming to boost energy and cognitive performance, and sports drinks designed to prevent dehydration and replenish electrolytes and carbohydrates lost during physical exertion.

Objective: To assess the nutritional quality of energy and sports drinks in Egypt.

Material and Methods: A cross-sectional study assessed the nutrient contents, including energy, sugar, electrolytes, vitamins, and caffeine, of sports and energy drinks available in major supermarkets in Cairo, Alexandria, and Giza, Egypt. Data collection involved photographing all relevant product labels and recording nutritional information. Descriptive statistics and appropriate statistical tests were employed to analyze and compare the nutritional values of energy and sports drinks.

Results: The study analyzed 38 sports drinks and 42 energy drinks. Sports drinks were significantly more expensive than energy drinks, with higher net content and elevated magnesium, potassium, and vitamin C. Energy drinks contained higher concentrations of caffeine, sugars, and vitamins B2, B3, and B6.

Conclusion: Significant nutritional differences exist between sports and energy drinks, reflecting their intended uses. However, these beverages’ high sugar content and calorie loads raise health concerns. Proper labeling, public awareness, and responsible marketing are essential to guide safe consumption practices in Egypt.

What is a research paper?

A research paper is a paper that makes an argument about a topic based on research and analysis.

Any paper requiring the writer to research a particular topic is a research paper. Unlike essays, which are often based largely on opinion and are written from the author's point of view, research papers are based in fact.

A research paper requires you to form an opinion on a topic, research and gain expert knowledge on that topic, and then back up your own opinions and assertions with facts found through your thorough research.

➡️ Read more about  different types of research papers .

What is the difference between a research paper and a thesis?

A thesis is a large paper, or multi-chapter work, based on a topic relating to your field of study.

A thesis is a document students of higher education write to obtain an academic degree or qualification. Usually, it is longer than a research paper and takes multiple years to complete.

Generally associated with graduate/postgraduate studies, it is carried out under the supervision of a professor or other academic of the university.

A major difference between a research paper and a thesis is that:

• a research paper presents certain facts that have already been researched and explained by others
• a thesis starts with a certain scholarly question or statement, which then leads to further research and new findings

This means that a thesis requires the author to input original work and their own findings in a certain field, whereas the research paper can be completed with extensive research only.

➡️ Getting ready to start a research paper or thesis? Take a look at our guides on how to start a research paper or how to come up with a topic for your thesis .

Frequently Asked Questions about research papers

Take a look at this list of the top 21 Free Online Journal and Research Databases , such as ScienceOpen , Directory of Open Access Journals , ERIC , and many more.

Mason Porter, Professor at UCLA, explains in this forum post the main reasons to write a research paper:

• To create new knowledge and disseminate it.
• To teach science and how to write about it in an academic style.
• Some practical benefits: prestige, establishing credentials, requirements for grants or to help one get a future grant proposal, and so on.

Generally, people involved in the academia. Research papers are mostly written by higher education students and professional researchers.

Yes, a research paper is the same as a scientific paper. Both papers have the same purpose and format.

A major difference between a research paper and a thesis is that the former presents certain facts that have already been researched and explained by others, whereas the latter starts with a certain scholarly question or statement, which then leads to further research and new findings.

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How to Write and Publish a Research Paper for a Peer-Reviewed Journal

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• Published: 30 April 2020
• Volume 36 , pages 909–913, ( 2021 )

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Communicating research findings is an essential step in the research process. Often, peer-reviewed journals are the forum for such communication, yet many researchers are never taught how to write a publishable scientific paper. In this article, we explain the basic structure of a scientific paper and describe the information that should be included in each section. We also identify common pitfalls for each section and recommend strategies to avoid them. Further, we give advice about target journal selection and authorship. In the online resource 1 , we provide an example of a high-quality scientific paper, with annotations identifying the elements we describe in this article.

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Avoid common mistakes on your manuscript.

Introduction

Writing a scientific paper is an important component of the research process, yet researchers often receive little formal training in scientific writing. This is especially true in low-resource settings. In this article, we explain why choosing a target journal is important, give advice about authorship, provide a basic structure for writing each section of a scientific paper, and describe common pitfalls and recommendations for each section. In the online resource 1 , we also include an annotated journal article that identifies the key elements and writing approaches that we detail here. Before you begin your research, make sure you have ethical clearance from all relevant ethical review boards.

Select a Target Journal Early in the Writing Process

We recommend that you select a “target journal” early in the writing process; a “target journal” is the journal to which you plan to submit your paper. Each journal has a set of core readers and you should tailor your writing to this readership. For example, if you plan to submit a manuscript about vaping during pregnancy to a pregnancy-focused journal, you will need to explain what vaping is because readers of this journal may not have a background in this topic. However, if you were to submit that same article to a tobacco journal, you would not need to provide as much background information about vaping.

Information about a journal’s core readership can be found on its website, usually in a section called “About this journal” or something similar. For example, the Journal of Cancer Education presents such information on the “Aims and Scope” page of its website, which can be found here: https://www.springer.com/journal/13187/aims-and-scope .

Peer reviewer guidelines from your target journal are an additional resource that can help you tailor your writing to the journal and provide additional advice about crafting an effective article [ 1 ]. These are not always available, but it is worth a quick web search to find out.

Identify Author Roles Early in the Process

Early in the writing process, identify authors, determine the order of authors, and discuss the responsibilities of each author. Standard author responsibilities have been identified by The International Committee of Medical Journal Editors (ICMJE) [ 2 ]. To set clear expectations about each team member’s responsibilities and prevent errors in communication, we also suggest outlining more detailed roles, such as who will draft each section of the manuscript, write the abstract, submit the paper electronically, serve as corresponding author, and write the cover letter. It is best to formalize this agreement in writing after discussing it, circulating the document to the author team for approval. We suggest creating a title page on which all authors are listed in the agreed-upon order. It may be necessary to adjust authorship roles and order during the development of the paper. If a new author order is agreed upon, be sure to update the title page in the manuscript draft.

In the case where multiple papers will result from a single study, authors should discuss who will author each paper. Additionally, authors should agree on a deadline for each paper and the lead author should take responsibility for producing an initial draft by this deadline.

Structure of the Introduction Section

The introduction section should be approximately three to five paragraphs in length. Look at examples from your target journal to decide the appropriate length. This section should include the elements shown in Fig.  1 . Begin with a general context, narrowing to the specific focus of the paper. Include five main elements: why your research is important, what is already known about the topic, the “gap” or what is not yet known about the topic, why it is important to learn the new information that your research adds, and the specific research aim(s) that your paper addresses. Your research aim should address the gap you identified. Be sure to add enough background information to enable readers to understand your study. Table 1 provides common introduction section pitfalls and recommendations for addressing them.

The main elements of the introduction section of an original research article. Often, the elements overlap

Methods Section

The purpose of the methods section is twofold: to explain how the study was done in enough detail to enable its replication and to provide enough contextual detail to enable readers to understand and interpret the results. In general, the essential elements of a methods section are the following: a description of the setting and participants, the study design and timing, the recruitment and sampling, the data collection process, the dataset, the dependent and independent variables, the covariates, the analytic approach for each research objective, and the ethical approval. The hallmark of an exemplary methods section is the justification of why each method was used. Table 2 provides common methods section pitfalls and recommendations for addressing them.

Results Section

The focus of the results section should be associations, or lack thereof, rather than statistical tests. Two considerations should guide your writing here. First, the results should present answers to each part of the research aim. Second, return to the methods section to ensure that the analysis and variables for each result have been explained.

Begin the results section by describing the number of participants in the final sample and details such as the number who were approached to participate, the proportion who were eligible and who enrolled, and the number of participants who dropped out. The next part of the results should describe the participant characteristics. After that, you may organize your results by the aim or by putting the most exciting results first. Do not forget to report your non-significant associations. These are still findings.

Tables and figures capture the reader’s attention and efficiently communicate your main findings [ 3 ]. Each table and figure should have a clear message and should complement, rather than repeat, the text. Tables and figures should communicate all salient details necessary for a reader to understand the findings without consulting the text. Include information on comparisons and tests, as well as information about the sample and timing of the study in the title, legend, or in a footnote. Note that figures are often more visually interesting than tables, so if it is feasible to make a figure, make a figure. To avoid confusing the reader, either avoid abbreviations in tables and figures, or define them in a footnote. Note that there should not be citations in the results section and you should not interpret results here. Table 3 provides common results section pitfalls and recommendations for addressing them.

Discussion Section

Opposite the introduction section, the discussion should take the form of a right-side-up triangle beginning with interpretation of your results and moving to general implications (Fig.  2 ). This section typically begins with a restatement of the main findings, which can usually be accomplished with a few carefully-crafted sentences.

Major elements of the discussion section of an original research article. Often, the elements overlap

Next, interpret the meaning or explain the significance of your results, lifting the reader’s gaze from the study’s specific findings to more general applications. Then, compare these study findings with other research. Are these findings in agreement or disagreement with those from other studies? Does this study impart additional nuance to well-accepted theories? Situate your findings within the broader context of scientific literature, then explain the pathways or mechanisms that might give rise to, or explain, the results.

Journals vary in their approach to strengths and limitations sections: some are embedded paragraphs within the discussion section, while some mandate separate section headings. Keep in mind that every study has strengths and limitations. Candidly reporting yours helps readers to correctly interpret your research findings.

The next element of the discussion is a summary of the potential impacts and applications of the research. Should these results be used to optimally design an intervention? Does the work have implications for clinical protocols or public policy? These considerations will help the reader to further grasp the possible impacts of the presented work.

Finally, the discussion should conclude with specific suggestions for future work. Here, you have an opportunity to illuminate specific gaps in the literature that compel further study. Avoid the phrase “future research is necessary” because the recommendation is too general to be helpful to readers. Instead, provide substantive and specific recommendations for future studies. Table 4 provides common discussion section pitfalls and recommendations for addressing them.

Follow the Journal’s Author Guidelines

After you select a target journal, identify the journal’s author guidelines to guide the formatting of your manuscript and references. Author guidelines will often (but not always) include instructions for titles, cover letters, and other components of a manuscript submission. Read the guidelines carefully. If you do not follow the guidelines, your article will be sent back to you.

Finally, do not submit your paper to more than one journal at a time. Even if this is not explicitly stated in the author guidelines of your target journal, it is considered inappropriate and unprofessional.

Your title should invite readers to continue reading beyond the first page [ 4 , 5 ]. It should be informative and interesting. Consider describing the independent and dependent variables, the population and setting, the study design, the timing, and even the main result in your title. Because the focus of the paper can change as you write and revise, we recommend you wait until you have finished writing your paper before composing the title.

Be sure that the title is useful for potential readers searching for your topic. The keywords you select should complement those in your title to maximize the likelihood that a researcher will find your paper through a database search. Avoid using abbreviations in your title unless they are very well known, such as SNP, because it is more likely that someone will use a complete word rather than an abbreviation as a search term to help readers find your paper.

After you have written a complete draft, use the checklist (Fig. 3 ) below to guide your revisions and editing. Additional resources are available on writing the abstract and citing references [ 5 ]. When you feel that your work is ready, ask a trusted colleague or two to read the work and provide informal feedback. The box below provides a checklist that summarizes the key points offered in this article.

Checklist for manuscript quality

Data Availability

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Lang TA (2017) Writing a better research article. J Public Health Emerg. https://doi.org/10.21037/jphe.2017.11.06

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Ella August is grateful to the Sustainable Sciences Institute for mentoring her in training researchers on writing and publishing their research.

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Busse, C., August, E. How to Write and Publish a Research Paper for a Peer-Reviewed Journal. J Canc Educ 36 , 909–913 (2021). https://doi.org/10.1007/s13187-020-01751-z

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WRITING A SCIENTIFIC RESEARCH ARTICLE | Format for the paper | Edit your paper! | Useful books | FORMAT FOR THE PAPER Scientific research articles provide a method for scientists to communicate with other scientists about the results of their research. A standard format is used for these articles, in which the author presents the research in an orderly, logical manner. This doesn't necessarily reflect the order in which you did or thought about the work.  This format is: | Title | Authors | Introduction | Materials and Methods | Results (with Tables and Figures ) | Discussion | Acknowledgments | Literature Cited | TITLE Make your title specific enough to describe the contents of the paper, but not so technical that only specialists will understand. The title should be appropriate for the intended audience. The title usually describes the subject matter of the article: Effect of Smoking on Academic Performance" Sometimes a title that summarizes the results is more effective: Students Who Smoke Get Lower Grades" AUTHORS 1. The person who did the work and wrote the paper is generally listed as the first author of a research paper. 2. For published articles, other people who made substantial contributions to the work are also listed as authors. Ask your mentor's permission before including his/her name as co-author. ABSTRACT 1. An abstract, or summary, is published together with a research article, giving the reader a "preview" of what's to come. Such abstracts may also be published separately in bibliographical sources, such as Biologic al Abstracts. They allow other scientists to quickly scan the large scientific literature, and decide which articles they want to read in depth. The abstract should be a little less technical than the article itself; you don't want to dissuade your potent ial audience from reading your paper. 2. Your abstract should be one paragraph, of 100-250 words, which summarizes the purpose, methods, results and conclusions of the paper. 3. It is not easy to include all this information in just a few words. Start by writing a summary that includes whatever you think is important, and then gradually prune it down to size by removing unnecessary words, while still retaini ng the necessary concepts. 3. Don't use abbreviations or citations in the abstract. It should be able to stand alone without any footnotes. INTRODUCTION What question did you ask in your experiment? Why is it interesting? The introduction summarizes the relevant literature so that the reader will understand why you were interested in the question you asked. One to fo ur paragraphs should be enough. End with a sentence explaining the specific question you asked in this experiment. MATERIALS AND METHODS 1. How did you answer this question? There should be enough information here to allow another scientist to repeat your experiment. Look at other papers that have been published in your field to get some idea of what is included in this section. 2. If you had a complicated protocol, it may helpful to include a diagram, table or flowchart to explain the methods you used. 3. Do not put results in this section. You may, however, include preliminary results that were used to design the main experiment that you are reporting on. ("In a preliminary study, I observed the owls for one week, and found that 73 % of their locomotor activity occurred during the night, and so I conducted all subsequent experiments between 11 pm and 6 am.") 4. Mention relevant ethical considerations. If you used human subjects, did they consent to participate. If you used animals, what measures did you take to minimize pain? RESULTS 1. This is where you present the results you've gotten. Use graphs and tables if appropriate, but also summarize your main findings in the text. Do NOT discuss the results or speculate as to why something happened; t hat goes in th e Discussion. 2. You don't necessarily have to include all the data you've gotten during the semester. This isn't a diary. 3. Use appropriate methods of showing data. Don't try to manipulate the data to make it look like you did more than you actually did. "The drug cured 1/3 of the infected mice, another 1/3 were not affected, and the third mouse got away." TABLES AND GRAPHS 1. If you present your data in a table or graph, include a title describing what's in the table ("Enzyme activity at various temperatures", not "My results".) For graphs, you should also label the x and y axes. 2. Don't use a table or graph just to be "fancy". If you can summarize the information in one sentence, then a table or graph is not necessary. DISCUSSION 1. Highlight the most significant results, but don't just repeat what you've written in the Results section. How do these results relate to the original question? Do the data support your hypothesis? Are your results consistent with what other investigators have reported? If your results were unexpected, try to explain why. Is there another way to interpret your results? What further research would be necessary to answer the questions raised by your results? How do y our results fit into the big picture? 2. End with a one-sentence summary of your conclusion, emphasizing why it is relevant. ACKNOWLEDGMENTS This section is optional. You can thank those who either helped with the experiments, or made other important contributions, such as discussing the protocol, commenting on the manuscript, or buying you pizza. REFERENCES (LITERATURE CITED) There are several possible ways to organize this section. Here is one commonly used way: 1. In the text, cite the literature in the appropriate places: Scarlet (1990) thought that the gene was present only in yeast, but it has since been identified in the platypus (Indigo and Mauve, 1994) and wombat (Magenta, et al., 1995). 2. In the References section list citations in alphabetical order. Indigo, A. C., and Mauve, B. E. 1994. Queer place for qwerty: gene isolation from the platypus. Science 275, 1213-1214. Magenta, S. T., Sepia, X., and Turquoise, U. 1995. Wombat genetics. In: Widiculous Wombats, Violet, Q., ed. New York: Columbia University Press. p 123-145. Scarlet, S.L. 1990. Isolation of qwerty gene from S. cerevisae. Journal of Unusual Results 36, 26-31.   EDIT YOUR PAPER!!! "In my writing, I average about ten pages a day. Unfortunately, they're all the same page." Michael Alley, The Craft of Scientific Writing A major part of any writing assignment consists of re-writing. Write accurately Scientific writing must be accurate. Although writing instructors may tell you not to use the same word twice in a sentence, it's okay for scientific writing, which must be accurate. (A student who tried not to repeat the word "hamster" produced this confusing sentence: "When I put the hamster in a cage with the other animals, the little mammals began to play.") Make sure you say what you mean. Instead of: The rats were injected with the drug. (sounds like a syringe was filled with drug and ground-up rats and both were injected together) Write: I injected the drug into the rat.

• Be careful with commonly confused words:

Temperature has an effect on the reaction. Temperature affects the reaction.

I used solutions in various concentrations. (The solutions were 5 mg/ml, 10 mg/ml, and 15 mg/ml) I used solutions in varying concentrations. (The concentrations I used changed; sometimes they were 5 mg/ml, other times they were 15 mg/ml.)

 Less food (can't count numbers of food) Fewer animals (can count numbers of animals)

A large amount of food (can't count them) A large number of animals (can count them)

The erythrocytes, which are in the blood, contain hemoglobin. The erythrocytes that are in the blood contain hemoglobin. (Wrong. This sentence implies that there are erythrocytes elsewhere that don't contain hemoglobin.)

Write clearly

1. Write at a level that's appropriate for your audience.

"Like a pigeon, something to admire as long as it isn't over your head." Anonymous

 2. Use the active voice. It's clearer and more concise than the passive voice.

 Instead of: An increased appetite was manifested by the rats and an increase in body weight was measured. Write: The rats ate more and gained weight.

 3. Use the first person.

 Instead of: It is thought Write: I think

 Instead of: The samples were analyzed Write: I analyzed the samples

 4. Avoid dangling participles.

 "After incubating at 30 degrees C, we examined the petri plates." (You must've been pretty warm in there.)

  Write succinctly

 1. Use verbs instead of abstract nouns

 Instead of: take into consideration Write: consider

 2. Use strong verbs instead of "to be"

 Instead of: The enzyme was found to be the active agent in catalyzing... Write: The enzyme catalyzed...

 3. Use short words.

Instead of: Write: possess have sufficient enough utilize use demonstrate show assistance help terminate end

4. Use concise terms.

 Instead of: Write: prior to before due to the fact that because in a considerable number of cases often the vast majority of most during the time that when in close proximity to near it has long been known that I'm too lazy to look up the reference

5. Use short sentences. A sentence made of more than 40 words should probably be rewritten as two sentences.

 "The conjunction 'and' commonly serves to indicate that the writer's mind still functions even when no signs of the phenomenon are noticeable." Rudolf Virchow, 1928

Check your grammar, spelling and punctuation

1. Use a spellchecker, but be aware that they don't catch all mistakes.

 "When we consider the animal as a hole,..." Student's paper

 2. Your spellchecker may not recognize scientific terms. For the correct spelling, try Biotech's Life Science Dictionary or one of the technical dictionaries on the reference shelf in the Biology or Health Sciences libraries.

 3. Don't, use, unnecessary, commas.

 4. Proofread carefully to see if you any words out.

USEFUL BOOKS

Victoria E. McMillan, Writing Papers in the Biological Sciences , Bedford Books, Boston, 1997 The best. On sale for about $18 at Labyrinth Books, 112th Street. On reserve in Biology Library

Jan A. Pechenik, A Short Guide to Writing About Biology , Boston: Little, Brown, 1987

Harrison W. Ambrose, III & Katharine Peckham Ambrose, A Handbook of Biological Investigation , 4th edition, Hunter Textbooks Inc, Winston-Salem, 1987 Particularly useful if you need to use statistics to analyze your data. Copy on Reference shelf in Biology Library.

Robert S. Day, How to Write and Publish a Scientific Paper , 4th edition, Oryx Press, Phoenix, 1994. Earlier editions also good. A bit more advanced, intended for those writing papers for publication. Fun to read. Several copies available in Columbia libraries.

William Strunk, Jr. and E. B. White, The Elements of Style , 3rd ed. Macmillan, New York, 1987. Several copies available in Columbia libraries.  Strunk's first edition is available on-line.

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What is Scientific Research and How Can it be Done?

Scientific researches are studies that should be systematically planned before performing them. In this review, classification and description of scientific studies, planning stage randomisation and bias are explained.

Research conducted for the purpose of contributing towards science by the systematic collection, interpretation and evaluation of data and that, too, in a planned manner is called scientific research: a researcher is the one who conducts this research. The results obtained from a small group through scientific studies are socialised, and new information is revealed with respect to diagnosis, treatment and reliability of applications. The purpose of this review is to provide information about the definition, classification and methodology of scientific research.

Before beginning the scientific research, the researcher should determine the subject, do planning and specify the methodology. In the Declaration of Helsinki, it is stated that ‘the primary purpose of medical researches on volunteers is to understand the reasons, development and effects of diseases and develop protective, diagnostic and therapeutic interventions (method, operation and therapies). Even the best proven interventions should be evaluated continuously by investigations with regard to reliability, effectiveness, efficiency, accessibility and quality’ ( 1 ).

The questions, methods of response to questions and difficulties in scientific research may vary, but the design and structure are generally the same ( 2 ).

Classification of Scientific Research

Scientific research can be classified in several ways. Classification can be made according to the data collection techniques based on causality, relationship with time and the medium through which they are applied.

• Observational
• Experimental
• Descriptive
• Retrospective
• Prospective
• Cross-sectional
• Social descriptive research ( 3 )

Another method is to classify the research according to its descriptive or analytical features. This review is written according to this classification method.

I. Descriptive research

• Case series
• Surveillance studies

II. Analytical research

• Observational studies: cohort, case control and cross- sectional research
• Interventional research: quasi-experimental and clinical research
• Case Report: it is the most common type of descriptive study. It is the examination of a single case having a different quality in the society, e.g. conducting general anaesthesia in a pregnant patient with mucopolysaccharidosis.
• Case Series: it is the description of repetitive cases having common features. For instance; case series involving interscapular pain related to neuraxial labour analgesia. Interestingly, malignant hyperthermia cases are not accepted as case series since they are rarely seen during historical development.
• Surveillance Studies: these are the results obtained from the databases that follow and record a health problem for a certain time, e.g. the surveillance of cross-infections during anaesthesia in the intensive care unit.

Moreover, some studies may be experimental. After the researcher intervenes, the researcher waits for the result, observes and obtains data. Experimental studies are, more often, in the form of clinical trials or laboratory animal trials ( 2 ).

Analytical observational research can be classified as cohort, case-control and cross-sectional studies.

Firstly, the participants are controlled with regard to the disease under investigation. Patients are excluded from the study. Healthy participants are evaluated with regard to the exposure to the effect. Then, the group (cohort) is followed-up for a sufficient period of time with respect to the occurrence of disease, and the progress of disease is studied. The risk of the healthy participants getting sick is considered an incident. In cohort studies, the risk of disease between the groups exposed and not exposed to the effect is calculated and rated. This rate is called relative risk. Relative risk indicates the strength of exposure to the effect on the disease.

Cohort research may be observational and experimental. The follow-up of patients prospectively is called a prospective cohort study . The results are obtained after the research starts. The researcher’s following-up of cohort subjects from a certain point towards the past is called a retrospective cohort study . Prospective cohort studies are more valuable than retrospective cohort studies: this is because in the former, the researcher observes and records the data. The researcher plans the study before the research and determines what data will be used. On the other hand, in retrospective studies, the research is made on recorded data: no new data can be added.

In fact, retrospective and prospective studies are not observational. They determine the relationship between the date on which the researcher has begun the study and the disease development period. The most critical disadvantage of this type of research is that if the follow-up period is long, participants may leave the study at their own behest or due to physical conditions. Cohort studies that begin after exposure and before disease development are called ambidirectional studies . Public healthcare studies generally fall within this group, e.g. lung cancer development in smokers.

• Case-Control Studies: these studies are retrospective cohort studies. They examine the cause and effect relationship from the effect to the cause. The detection or determination of data depends on the information recorded in the past. The researcher has no control over the data ( 2 ).

Cross-sectional studies are advantageous since they can be concluded relatively quickly. It may be difficult to obtain a reliable result from such studies for rare diseases ( 2 ).

Cross-sectional studies are characterised by timing. In such studies, the exposure and result are simultaneously evaluated. While cross-sectional studies are restrictedly used in studies involving anaesthesia (since the process of exposure is limited), they can be used in studies conducted in intensive care units.

• Quasi-Experimental Research: they are conducted in cases in which a quick result is requested and the participants or research areas cannot be randomised, e.g. giving hand-wash training and comparing the frequency of nosocomial infections before and after hand wash.
• Clinical Research: they are prospective studies carried out with a control group for the purpose of comparing the effect and value of an intervention in a clinical case. Clinical study and research have the same meaning. Drugs, invasive interventions, medical devices and operations, diets, physical therapy and diagnostic tools are relevant in this context ( 6 ).

Clinical studies are conducted by a responsible researcher, generally a physician. In the research team, there may be other healthcare staff besides physicians. Clinical studies may be financed by healthcare institutes, drug companies, academic medical centres, volunteer groups, physicians, healthcare service providers and other individuals. They may be conducted in several places including hospitals, universities, physicians’ offices and community clinics based on the researcher’s requirements. The participants are made aware of the duration of the study before their inclusion. Clinical studies should include the evaluation of recommendations (drug, device and surgical) for the treatment of a disease, syndrome or a comparison of one or more applications; finding different ways for recognition of a disease or case and prevention of their recurrence ( 7 ).

Clinical Research

In this review, clinical research is explained in more detail since it is the most valuable study in scientific research.

Clinical research starts with forming a hypothesis. A hypothesis can be defined as a claim put forward about the value of a population parameter based on sampling. There are two types of hypotheses in statistics.

• H 0 hypothesis is called a control or null hypothesis. It is the hypothesis put forward in research, which implies that there is no difference between the groups under consideration. If this hypothesis is rejected at the end of the study, it indicates that a difference exists between the two treatments under consideration.
• H 1 hypothesis is called an alternative hypothesis. It is hypothesised against a null hypothesis, which implies that a difference exists between the groups under consideration. For example, consider the following hypothesis: drug A has an analgesic effect. Control or null hypothesis (H 0 ): there is no difference between drug A and placebo with regard to the analgesic effect. The alternative hypothesis (H 1 ) is applicable if a difference exists between drug A and placebo with regard to the analgesic effect.

The planning phase comes after the determination of a hypothesis. A clinical research plan is called a protocol . In a protocol, the reasons for research, number and qualities of participants, tests to be applied, study duration and what information to be gathered from the participants should be found and conformity criteria should be developed.

The selection of participant groups to be included in the study is important. Inclusion and exclusion criteria of the study for the participants should be determined. Inclusion criteria should be defined in the form of demographic characteristics (age, gender, etc.) of the participant group and the exclusion criteria as the diseases that may influence the study, age ranges, cases involving pregnancy and lactation, continuously used drugs and participants’ cooperation.

The next stage is methodology. Methodology can be grouped under subheadings, namely, the calculation of number of subjects, blinding (masking), randomisation, selection of operation to be applied, use of placebo and criteria for stopping and changing the treatment.

I. Calculation of the Number of Subjects

The entire source from which the data are obtained is called a universe or population . A small group selected from a certain universe based on certain rules and which is accepted to highly represent the universe from which it is selected is called a sample and the characteristics of the population from which the data are collected are called variables. If data is collected from the entire population, such an instance is called a parameter . Conducting a study on the sample rather than the entire population is easier and less costly. Many factors influence the determination of the sample size. Firstly, the type of variable should be determined. Variables are classified as categorical (qualitative, non-numerical) or numerical (quantitative). Individuals in categorical variables are classified according to their characteristics. Categorical variables are indicated as nominal and ordinal (ordered). In nominal variables, the application of a category depends on the researcher’s preference. For instance, a female participant can be considered first and then the male participant, or vice versa. An ordinal (ordered) variable is ordered from small to large or vice versa (e.g. ordering obese patients based on their weights-from the lightest to the heaviest or vice versa). A categorical variable may have more than one characteristic: such variables are called binary or dichotomous (e.g. a participant may be both female and obese).

If the variable has numerical (quantitative) characteristics and these characteristics cannot be categorised, then it is called a numerical variable. Numerical variables are either discrete or continuous. For example, the number of operations with spinal anaesthesia represents a discrete variable. The haemoglobin value or height represents a continuous variable.

Statistical analyses that need to be employed depend on the type of variable. The determination of variables is necessary for selecting the statistical method as well as software in SPSS. While categorical variables are presented as numbers and percentages, numerical variables are represented using measures such as mean and standard deviation. It may be necessary to use mean in categorising some cases such as the following: even though the variable is categorical (qualitative, non-numerical) when Visual Analogue Scale (VAS) is used (since a numerical value is obtained), it is classified as a numerical variable: such variables are averaged.

Clinical research is carried out on the sample and generalised to the population. Accordingly, the number of samples should be correctly determined. Different sample size formulas are used on the basis of the statistical method to be used. When the sample size increases, error probability decreases. The sample size is calculated based on the primary hypothesis. The determination of a sample size before beginning the research specifies the power of the study. Power analysis enables the acquisition of realistic results in the research, and it is used for comparing two or more clinical research methods.

Because of the difference in the formulas used in calculating power analysis and number of samples for clinical research, it facilitates the use of computer programs for making calculations.

It is necessary to know certain parameters in order to calculate the number of samples by power analysis.

• Type-I (α) and type-II (β) error levels
• Difference between groups (d-difference) and effect size (ES)
• Distribution ratio of groups
• Direction of research hypothesis (H1)

a. Type-I (α) and Type-II (β) Error (β) Levels

Two types of errors can be made while accepting or rejecting H 0 hypothesis in a hypothesis test. Type-I error (α) level is the probability of finding a difference at the end of the research when there is no difference between the two applications. In other words, it is the rejection of the hypothesis when H 0 is actually correct and it is known as α error or p value. For instance, when the size is determined, type-I error level is accepted as 0.05 or 0.01.

Another error that can be made during a hypothesis test is a type-II error. It is the acceptance of a wrongly hypothesised H 0 hypothesis. In fact, it is the probability of failing to find a difference when there is a difference between the two applications. The power of a test is the ability of that test to find a difference that actually exists. Therefore, it is related to the type-II error level.

Since the type-II error risk is expressed as β, the power of the test is defined as 1–β. When a type-II error is 0.20, the power of the test is 0.80. Type-I (α) and type-II (β) errors can be intentional. The reason to intentionally make such an error is the necessity to look at the events from the opposite perspective.

b. Difference between Groups and ES

ES is defined as the state in which statistical difference also has clinically significance: ES≥0.5 is desirable. The difference between groups is the absolute difference between the groups compared in clinical research.

c. Allocation Ratio of Groups

The allocation ratio of groups is effective in determining the number of samples. If the number of samples is desired to be determined at the lowest level, the rate should be kept as 1/1.

d. Direction of Hypothesis (H1)

The direction of hypothesis in clinical research may be one-sided or two-sided. While one-sided hypotheses hypothesis test differences in the direction of size, two-sided hypotheses hypothesis test differences without direction. The power of the test in two-sided hypotheses is lower than one-sided hypotheses.

After these four variables are determined, they are entered in the appropriate computer program and the number of samples is calculated. Statistical packaged software programs such as Statistica, NCSS and G-Power may be used for power analysis and calculating the number of samples. When the samples size is calculated, if there is a decrease in α, difference between groups, ES and number of samples, then the standard deviation increases and power decreases. The power in two-sided hypothesis is lower. It is ethically appropriate to consider the determination of sample size, particularly in animal experiments, at the beginning of the study. The phase of the study is also important in the determination of number of subjects to be included in drug studies. Usually, phase-I studies are used to determine the safety profile of a drug or product, and they are generally conducted on a few healthy volunteers. If no unacceptable toxicity is detected during phase-I studies, phase-II studies may be carried out. Phase-II studies are proof-of-concept studies conducted on a larger number (100–500) of volunteer patients. When the effectiveness of the drug or product is evident in phase-II studies, phase-III studies can be initiated. These are randomised, double-blinded, placebo or standard treatment-controlled studies. Volunteer patients are periodically followed-up with respect to the effectiveness and side effects of the drug. It can generally last 1–4 years and is valuable during licensing and releasing the drug to the general market. Then, phase-IV studies begin in which long-term safety is investigated (indication, dose, mode of application, safety, effectiveness, etc.) on thousands of volunteer patients.

II. Blinding (Masking) and Randomisation Methods

When the methodology of clinical research is prepared, precautions should be taken to prevent taking sides. For this reason, techniques such as randomisation and blinding (masking) are used. Comparative studies are the most ideal ones in clinical research.

Blinding Method

A case in which the treatments applied to participants of clinical research should be kept unknown is called the blinding method . If the participant does not know what it receives, it is called a single-blind study; if even the researcher does not know, it is called a double-blind study. When there is a probability of knowing which drug is given in the order of application, when uninformed staff administers the drug, it is called in-house blinding. In case the study drug is known in its pharmaceutical form, a double-dummy blinding test is conducted. Intravenous drug is given to one group and a placebo tablet is given to the comparison group; then, the placebo tablet is given to the group that received the intravenous drug and intravenous drug in addition to placebo tablet is given to the comparison group. In this manner, each group receives both the intravenous and tablet forms of the drug. In case a third party interested in the study is involved and it also does not know about the drug (along with the statistician), it is called third-party blinding.

Randomisation Method

The selection of patients for the study groups should be random. Randomisation methods are used for such selection, which prevent conscious or unconscious manipulations in the selection of patients ( 8 ).

No factor pertaining to the patient should provide preference of one treatment to the other during randomisation. This characteristic is the most important difference separating randomised clinical studies from prospective and synchronous studies with experimental groups. Randomisation strengthens the study design and enables the determination of reliable scientific knowledge ( 2 ).

The easiest method is simple randomisation, e.g. determination of the type of anaesthesia to be administered to a patient by tossing a coin. In this method, when the number of samples is kept high, a balanced distribution is created. When the number of samples is low, there will be an imbalance between the groups. In this case, stratification and blocking have to be added to randomisation. Stratification is the classification of patients one or more times according to prognostic features determined by the researcher and blocking is the selection of a certain number of patients for each stratification process. The number of stratification processes should be determined at the beginning of the study.

As the number of stratification processes increases, performing the study and balancing the groups become difficult. For this reason, stratification characteristics and limitations should be effectively determined at the beginning of the study. It is not mandatory for the stratifications to have equal intervals. Despite all the precautions, an imbalance might occur between the groups before beginning the research. In such circumstances, post-stratification or restandardisation may be conducted according to the prognostic factors.

The main characteristic of applying blinding (masking) and randomisation is the prevention of bias. Therefore, it is worthwhile to comprehensively examine bias at this stage.

Bias and Chicanery

While conducting clinical research, errors can be introduced voluntarily or involuntarily at a number of stages, such as design, population selection, calculating the number of samples, non-compliance with study protocol, data entry and selection of statistical method. Bias is taking sides of individuals in line with their own decisions, views and ideological preferences ( 9 ). In order for an error to lead to bias, it has to be a systematic error. Systematic errors in controlled studies generally cause the results of one group to move in a different direction as compared to the other. It has to be understood that scientific research is generally prone to errors. However, random errors (or, in other words, ‘the luck factor’-in which bias is unintended-do not lead to bias ( 10 ).

Another issue, which is different from bias, is chicanery. It is defined as voluntarily changing the interventions, results and data of patients in an unethical manner or copying data from other studies. Comparatively, bias may not be done consciously.

In case unexpected results or outliers are found while the study is analysed, if possible, such data should be re-included into the study since the complete exclusion of data from a study endangers its reliability. In such a case, evaluation needs to be made with and without outliers. It is insignificant if no difference is found. However, if there is a difference, the results with outliers are re-evaluated. If there is no error, then the outlier is included in the study (as the outlier may be a result). It should be noted that re-evaluation of data in anaesthesiology is not possible.

Statistical evaluation methods should be determined at the design stage so as not to encounter unexpected results in clinical research. The data should be evaluated before the end of the study and without entering into details in research that are time-consuming and involve several samples. This is called an interim analysis . The date of interim analysis should be determined at the beginning of the study. The purpose of making interim analysis is to prevent unnecessary cost and effort since it may be necessary to conclude the research after the interim analysis, e.g. studies in which there is no possibility to validate the hypothesis at the end or the occurrence of different side effects of the drug to be used. The accuracy of the hypothesis and number of samples are compared. Statistical significance levels in interim analysis are very important. If the data level is significant, the hypothesis is validated even if the result turns out to be insignificant after the date of the analysis.

Another important point to be considered is the necessity to conclude the participants’ treatment within the period specified in the study protocol. When the result of the study is achieved earlier and unexpected situations develop, the treatment is concluded earlier. Moreover, the participant may quit the study at its own behest, may die or unpredictable situations (e.g. pregnancy) may develop. The participant can also quit the study whenever it wants, even if the study has not ended ( 7 ).

In case the results of a study are contrary to already known or expected results, the expected quality level of the study suggesting the contradiction may be higher than the studies supporting what is known in that subject. This type of bias is called confirmation bias. The presence of well-known mechanisms and logical inference from them may create problems in the evaluation of data. This is called plausibility bias.

Another type of bias is expectation bias. If a result different from the known results has been achieved and it is against the editor’s will, it can be challenged. Bias may be introduced during the publication of studies, such as publishing only positive results, selection of study results in a way to support a view or prevention of their publication. Some editors may only publish research that extols only the positive results or results that they desire.

Bias may be introduced for advertisement or economic reasons. Economic pressure may be applied on the editor, particularly in the cases of studies involving drugs and new medical devices. This is called commercial bias.

In recent years, before beginning a study, it has been recommended to record it on the Web site www.clinicaltrials.gov for the purpose of facilitating systematic interpretation and analysis in scientific research, informing other researchers, preventing bias, provision of writing in a standard format, enhancing contribution of research results to the general literature and enabling early intervention of an institution for support. This Web site is a service of the US National Institutes of Health.

The last stage in the methodology of clinical studies is the selection of intervention to be conducted. Placebo use assumes an important place in interventions. In Latin, placebo means ‘I will be fine’. In medical literature, it refers to substances that are not curative, do not have active ingredients and have various pharmaceutical forms. Although placebos do not have active drug characteristic, they have shown effective analgesic characteristics, particularly in algology applications; further, its use prevents bias in comparative studies. If a placebo has a positive impact on a participant, it is called the placebo effect ; on the contrary, if it has a negative impact, it is called the nocebo effect . Another type of therapy that can be used in clinical research is sham application. Although a researcher does not cure the patient, the researcher may compare those who receive therapy and undergo sham. It has been seen that sham therapies also exhibit a placebo effect. In particular, sham therapies are used in acupuncture applications ( 11 ). While placebo is a substance, sham is a type of clinical application.

Ethically, the patient has to receive appropriate therapy. For this reason, if its use prevents effective treatment, it causes great problem with regard to patient health and legalities.

Before medical research is conducted with human subjects, predictable risks, drawbacks and benefits must be evaluated for individuals or groups participating in the study. Precautions must be taken for reducing the risk to a minimum level. The risks during the study should be followed, evaluated and recorded by the researcher ( 1 ).

After the methodology for a clinical study is determined, dealing with the ‘Ethics Committee’ forms the next stage. The purpose of the ethics committee is to protect the rights, safety and well-being of volunteers taking part in the clinical research, considering the scientific method and concerns of society. The ethics committee examines the studies presented in time, comprehensively and independently, with regard to ethics and science; in line with the Declaration of Helsinki and following national and international standards concerning ‘Good Clinical Practice’. The method to be followed in the formation of the ethics committee should be developed without any kind of prejudice and to examine the applications with regard to ethics and science within the framework of the ethics committee, Regulation on Clinical Trials and Good Clinical Practice ( www.iku.com ). The necessary documents to be presented to the ethics committee are research protocol, volunteer consent form, budget contract, Declaration of Helsinki, curriculum vitae of researchers, similar or explanatory literature samples, supporting institution approval certificate and patient follow-up form.

Only one sister/brother, mother, father, son/daughter and wife/husband can take charge in the same ethics committee. A rector, vice rector, dean, deputy dean, provincial healthcare director and chief physician cannot be members of the ethics committee.

Members of the ethics committee can work as researchers or coordinators in clinical research. However, during research meetings in which members of the ethics committee are researchers or coordinators, they must leave the session and they cannot sign-off on decisions. If the number of members in the ethics committee for a particular research is so high that it is impossible to take a decision, the clinical research is presented to another ethics committee in the same province. If there is no ethics committee in the same province, an ethics committee in the closest settlement is found.

Thereafter, researchers need to inform the participants using an informed consent form. This form should explain the content of clinical study, potential benefits of the study, alternatives and risks (if any). It should be easy, comprehensible, conforming to spelling rules and written in plain language understandable by the participant.

This form assists the participants in taking a decision regarding participation in the study. It should aim to protect the participants. The participant should be included in the study only after it signs the informed consent form; the participant can quit the study whenever required, even when the study has not ended ( 7 ).

Peer-review: Externally peer-reviewed.

Author Contributions: Concept - C.Ö.Ç., A.D.; Design - C.Ö.Ç.; Supervision - A.D.; Resource - C.Ö.Ç., A.D.; Materials - C.Ö.Ç., A.D.; Analysis and/or Interpretation - C.Ö.Ç., A.D.; Literature Search - C.Ö.Ç.; Writing Manuscript - C.Ö.Ç.; Critical Review - A.D.; Other - C.Ö.Ç., A.D.

Conflict of Interest: No conflict of interest was declared by the authors.

Financial Disclosure: The authors declared that this study has received no financial support.

Research Paper

• Icon Calendar 11 June 2024
• Icon Page 2825 words
• Icon Clock 13 min read

A research paper is a product of seeking information, analysis, human thinking, and time. Basically, when scholars want to get answers to questions, they start to search for information to expand, use, approve, or deny findings. In simple words, research papers are results of processes by considering writing works and following specific requirements. Besides, scientists study and expand many theories, developing social or technological aspects of human science. However, in order to provide a quality product, they need to know the definition of such a work, its characteristics, type, structure, format, and how to write it in 7 steps.

What Is a Research Paper and Its Purpose

According to its definition, a research paper is a detailed and structured academic document that presents an individual’s analysis, interpretation, or argument based on existing knowledge and literature. The main purpose of writing a research paper is to contribute to existing literature, develop critical thinking and scientific skills, support academic and professional growth, share findings, demonstrate knowledge and competence, and encourage lifelong learning (Wankhade, 2018). Moreover, such a work is one of the types of papers where scholars analyze questions or topics, look for secondary sources, and write papers on defined themes. For example, if an assignment is to write about some causes of global warming or any other topic, a person must write a research proposal on it, analyzing important points and credible sources (Goodson, 2024). Although essays focus on personal knowledge, writing a scholarly document means analyzing sources by following academic standards. In turn, scientists must meet the strict structure of research papers (Busse & August, 2020). As such, writers need to analyze their topics, start to search for sources, cover key aspects, process credible articles, and organize final studies properly. However, a research paper’s length can vary significantly depending on its academic level and purpose.

• Length: Typically 2-10 pages.
• Word Count: Approximately 500-2,500 words.
• Length: Usually 10-30 pages.
• Word Count: Around 2,500-7,500 words.
• Length: Master’s theses are generally 40-80 pages, while doctoral dissertations can be 100-300 pages or more.
• Word Count: Master’s theses are typically 10,000-20,000 words, and doctoral dissertations can range from 20,000-100,000 words, depending on the discipline and complexity.
• Length: Generally 8-12 pages for short articles, but review articles and comprehensive studies can be longer.
• Word Count: Approximately 3,000-8,000 words.
• Length: Usually 5-10 pages.
• Word Count: Around 2,000-4,000 words.
• Length: Typically 6-12 pages.
• Word Count: Approximately 2,500-6,000 words.
• Length: Varies widely, often 20-100 pages.
• Word Count: Around 5,000-30,000 words.
• Length: Generally 5-15 pages.
• Word Count: Approximately 2,000-5,000 words.
• Length: Varies, usually 20-40 pages per chapter.
• Word Count: Around 5,000-10,000 words.
• Length: Typically 100-300 pages.
• Word Count: Approximately 30,000-100,000 words.

Research Characteristics

Any type of work must meet some standards. By considering a research paper, this work must be written accordingly. In this case, their main characteristics are the length, style, format, and sources (Graham & McCoy, 2014). Firstly, the study’s length defines the number of needed sources to be analyzed. Then, the style must be formal and cover impersonal and inclusive language (Graham & McCoy, 2014). Moreover, the format means academic standards of how to organize final works, including its structure and norms. Finally, sources and their number define works as research papers because of the volume of analyzed information (Graham & McCoy, 2014). Hence, these characteristics must be considered while writing scholarly documents. In turn, general formatting guidelines are:

• Use a standard font (e.g., Times New Roman, 12-point).
• Double-space the text.
• Include 1-inch margins on all sides.
• Indent the first line of each paragraph.
• Number all pages consecutively, usually in the upper right corner.

Types of Research Papers

In general, the length of assignments can be different because of instructions. For example, there are two main types of research papers, such as typical and serious works. Firstly, a typical research paper may include definitive, argumentative, interpretive, and other works (Goodson, 2024). In this case, typical papers are from 2 to 10 pages, where students analyze study questions or specific topics. Then, a serious research composition is the expanded version of typical works. In turn, the length of such a paper is more than 10 pages (Wankhade, 2018). Basically, such works cover a serious analysis with many sources. Therefore, typical and serious works are two types that scholars should consider when writing their documents.

Typical Research Works

Basically, typical research works depend on assignments, the number of sources, and the paper’s length. So, this composition is usually a long essay with the analyzed evidence. For example, students in high school and college get such assignments to learn how to research and analyze topics (Goodson, 2024). In this case, they do not need to conduct serious experiments with the analysis and calculation of data. Moreover, students must use the Internet or libraries in searching for credible secondary sources to find potential answers to specific questions. As a result, students gather information on topics and learn how to take defined sides, present unique positions, or explain new directions (Goodson, 2024). Hence, they require an analysis of primary and secondary sources without serious experiments or data.

Serious Research Studies

Although long papers require a lot of time for finding and analyzing credible sources, real experiments are an integral part of research work. Firstly, scholars at universities need to analyze the information from past studies to expand or disapprove of topics (Wankhade, 2018). Then, if scholars want to prove specific positions or ideas, they must get real evidence. In this case, experiments can be surveys, calculations, or other types of data that scholars do personally. Moreover, a dissertation is a serious research paper that young scientists write based on the analysis of topics, data from conducted experiments, and conclusions at the end of work (Wankhade, 2018). Thus, they are studies that take a lot of time, analysis of sources with gained data, and interpretation of results.

The structure and format of research papers depend on assignment requirements. In fact, when students get their assignments and instructions, they need to analyze specific research questions or topics, find reliable sources, and write final works. Basically, their structure and format consist of the abstract, outline, introduction, literature review, methodology, results, discussion, recommendations, limitations, conclusion, acknowledgments, and references (Graham & McCoy, 2014). However, students may not include some of these sections because of assigned instructions that they have and specific types they must follow. For instance, if instructions are not supposed to conduct real experiments, the methodology section can be skipped because of the data’s absence. In turn, the structure of the final work consists of:

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🔸 The First Part of a Research Study

Abstract or Executive Summary means the first section of a research paper that provides the study’s purpose, its questions or suggestions, and main findings with conclusions. Moreover, this paragraph of about 150 words should be written when the whole work is finished already (Graham & McCoy, 2014). Hence, abstract sections should describe key aspects of studies, including discussions about the relevance of findings.

Outline or Table of Contents serves as a clear map of the structure of a study.

Introduction provides the main information on problem statements, the indication of methodology, important findings, and principal conclusion. Basically, this section covers rationales behind the work or background research, explanation of the importance, defending its relevance, a brief description of experimental designs, defined study questions, hypotheses, or key aspects (Busse & August, 2020). Hence, scholars should provide a short overview of their studies.

🔸 Literature Review and Research or Experiment

Literature Review is needed for the analysis of past studies or scholarly articles to be familiar with research questions or topics. For example, this section summarizes and synthesizes arguments and ideas from scholarly sources without adding new contributions (Scholz, 2022). In turn, this part is organized around arguments or ideas, not sources.

Methodology or Materials and Methods covers explanations of research designs. Basically, techniques for gathering information and other aspects related to experiments must be described in a research paper. For instance, students and scholars document all specialized materials and general procedures (Turbek et al., 2016). In this case, individuals may use some or all of the methods in further studies or judge the scientific merit of the work. Moreover, scientists should explain how they are going to conduct their experiments.

Results mean the gained information or data after the study or experiment. Basically, scholars should present and illustrate their findings (Turbek et al., 2016). Moreover, this section may include tables or figures.

🔸 Analysis of Findings

Discussion is a section where scientists review the information in the introduction part, evaluate gained results, or compare it with past studies. In particular, students and scholars interpret gained data or findings in appropriate depth. For example, if results differ from expectations at the beginning, scientists should explain why that may have happened (Turbek et al., 2016). However, if results agree with rationales, scientists should describe theories that the evidence is supported.

Recommendations take their roots from a discussion section where scholars propose potential solutions or new ideas based on obtained results. In this case, if scientists have any recommendations on how to improve this research so that other scholars can use evidence in further studies, they must write what they think in this section (Graham & McCoy, 2014). Besides, authors can provide their suggestions for further investigation after their evaluations.

Limitations mean a consideration of research weaknesses and results to get new directions. For instance, if scholars find any limitations in their studies that may affect experiments, scholars must not use such knowledge because of the same mistakes (Busse & August, 2020). Moreover, scientists should avoid contradicting results, and, even more, they must write them in this section.

🔸 The Final Part of a Conducted Research

Conclusion includes final claims of a research paper based on findings. Basically, this section covers final thoughts and the summary of the whole work. Moreover, this section may be used instead of limitations and recommendations that would be too small by themselves (Wankhade, 2018). In this case, scientists do not need to use headings as recommendations and limitations.

Acknowledgments or Appendix may take different forms, from paragraphs to charts. In this section, scholars include additional information about what they did.

References mean a section where students, scholars, or scientists provide all used sources by following the format and academic rules.

How to Write a Research Paper in 7 Steps

Writing any research paper requires following a systematic process. Firstly, writers need to select a focused topic they want to analyze. To achieve this objective, comprehensive preliminary research must be conducted to gather credible and relevant sources (Scholz, 2022). After reviewing the existing literature, writers must develop a clear and concise thesis statement sentence to guide the direction of their studies. Then, organizing the main arguments and evidence into a detailed outline ensures a coherent structure. In turn, the initial draft should be started with a compelling introduction, proceeded with body paragraphs that substantiate the thesis through analysis, and ended with a conclusion that underscores the study’s importance (Turbek et al., 2016). Basically, concluding the work by summarizing the findings and emphasizing the significance of the study is crucial. Moreover, revising and editing for content, coherence, and clarity ensures quality (Busse & August, 2020). Finally, proofreading for grammatical accuracy and ensuring adherence to the required formatting guidelines is necessary before submitting the final paper. Hence, when starting a research paper, writers should do the next:

Step 1: Choose a Topic

• Select a Broad Subject: Begin by identifying a specific subject or theme of interest.
• Narrow Down Your Topic: Focus on a specific aspect of the subject or theme to make your examination more focused.
• Establish the Background: Do a preliminary analysis of sources to ensure there is enough information available and refine your topic further.
• Formulate a Research Question : Create a first draft of a clear, concise research question or thesis statement to guide your study.

Step 2: Conduct Preliminary Analysis

• Gather Credible Sources: Use books, academic journals, scholarly articles, reputable websites, and other primary and secondary sources.
• Choose Only Relevant Sources: Review chosen sources for their content and pick only relevant ones.
• Take Notes: Organize your notes, highlighting key points and evidence and how they relate to your initial thesis.
• Create an Annotated Bibliography: Summarize each source in one paragraph and note how it will contribute to your paper.

Step 3: Develop a Working Thesis Statement

• Be Specific: Revise your initial thesis, making it a working one, outlining the main argument or position of your paper.
• Make It Debatable: Ensure that your working thesis presents a viewpoint that others might challenge or debate.
• Be Concise: Write your working thesis statement in one or two sentences.
• Stay Focused: Your working thesis must be focused and specific.

Step 4: Create an Outline

• Beginning: Outline your opening paragraph, including your working thesis statement.
• Middle Sections : Separate your body into sections with headings for each main point or argument and include sub-points and supporting evidence.
• Ending: Plan your concluding section to summarize your findings and restate your thesis in the light of the evidence presented.
• The List of Sources: Finish your outline by providing citation entries of your sources.

Step 5: Write the First Draft

• Introduction: Start with an engaging opening, provide background information, and state your thesis.
• Body Section: Each body paragraph should focus on a single idea and start with a specific topic sentence, followed by evidence and analysis that supports your thesis.
• Conclusion: Summarize your arguments, restate the importance of your topic, and suggest further investigation, analysis, examination, or possible implications.
• Reference Page: Include the list of references used in your first draft.

Step 6: Revise and Edit

• Content Review: Check for clarity, coherence, and whether each part supports your thesis.
• Structure and Flow: Ensure logical flow of ideas between sections and paragraphs.
• Grammar and Style: Correct grammatical errors, improve sentence structure, and refine your writing style.
• Citations: Ensure all sources are correctly cited in your chosen citation style (APA, MLA, Chicago/Turabian, Harvard, etc.).

Step 7: Finalize Your Paper

• Proofread: Carefully proofread for any remaining errors or typos.
• Format: Ensure your paper adheres to the required format, including title page, headers, font, and margins.
• Reference List: Double-check your bibliography, reference, or works cited page for accuracy.
• Submit: Make sure to submit your paper by the deadline.

In conclusion, a research paper is a formal academic document designed to provide a detailed analysis, interpretation, or argument based on in-depth study. Its structured format includes providing opening components, such as the abstract, outline, and introduction; study aspects, such as literature review, methodology, and results; analysis of findings, such as discussion, recommendations, and limitations; and final parts, such as conclusion, acknowledgments, appendices, and references. Understanding the essential elements and adhering to academic standards ensures the creation of a well-organized and meaningful research paper.

Busse, C., & August, E. (2020). How to write and publish a research paper for a peer-reviewed journal. Journal of Cancer Education , 36 (5), 909–913. https://doi.org/10.1007/s13187-020-01751-z

Goodson, P. (2024). Becoming an academic writer: 50 exercises for paced, productive, and powerful writing . Sage.

Graham, L., & McCoy, I. (2014). How to write a great research paper: A step-by-step handbook. Incentive Publications by World Book.

Scholz, F. (2022). Writing and publishing a scientific paper. ChemTexts , 8 (1), 1–7. https://doi.org/10.1007/s40828-022-00160-7

Turbek, S. P., Chock, T. M., Donahue, K., Havrilla, C. A., Oliverio, A. M., Polutchko, S. K., Shoemaker, L. G., & Vimercati, L. (2016). Scientific writing made easy: A step‐by‐step guide to undergraduate writing in the Biological Sciences. The Bulletin of the Ecological Society of America , 97 (4), 417–426. https://doi.org/10.1002/bes2.1258

Wankhade, L. (2018). How to write and publish a research paper: A complete guide to writing and publishing a research paper . Independent Published.

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Parts of a Technical Paper

The basic parts of a scientific or technical paper are:

Title and Author Information Abstract Introduction Literature Review Methods Results Discussion Conclusions References and Appendices

Detailed Explanation for Each Part

Title and Author Information:

The title of your paper and any needed information about yourself (usually your name and institution).

A short (usually around 250-400 words) description of the paper. Should include what the purpose of the paper is (including the basic research question/problem), the basic design of your project, and the major findings.

Introduction:

A general introduction to your topic and what you expect to learn from your project or experiment. Your research question should be found here.

Literature Review:

An analysis of what has already been published about your chosen topic. Should be able to show how your research question fits into the context of your field.

A description of everything you did in your experiment or project, step-by-step. Needs to be detailed enough so that any reader would be able to repeat each step exactly on their own.

What actually happened during your project or what you found at the end of your experiment. This is usually the best part to include the majority of your graphs, photos, tables, and other visual aids, as long as they help explain the results of your work.

Discussion:

An analysis of the results that integrates what you found into the wider body of research in your field. Can also include future hypotheses to be tested or future projects to build from your own.

Conclusion:

Can be included in the discussion if necessary. A final summary of the paper, including whether or not you were able to answer your original research question.

References and Appendices:

The reference page(s) is a list of all the sources you used to research and create your project/experiment, including everything cited in the literature review and methods sections. Remember to use the same citation style throughout the paper. An appendix would include any additional information about your work that you were not able to include within the body of your paper (like large datasets and figures) that would help readers better understand your results.

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How to Write a Research Proposal: (with Examples & Templates)

Table of Contents

Before conducting a study, a research proposal should be created that outlines researchers’ plans and methodology and is submitted to the concerned evaluating organization or person. Creating a research proposal is an important step to ensure that researchers are on track and are moving forward as intended. A research proposal can be defined as a detailed plan or blueprint for the proposed research that you intend to undertake. It provides readers with a snapshot of your project by describing what you will investigate, why it is needed, and how you will conduct the research.  

Your research proposal should aim to explain to the readers why your research is relevant and original, that you understand the context and current scenario in the field, have the appropriate resources to conduct the research, and that the research is feasible given the usual constraints.  

This article will describe in detail the purpose and typical structure of a research proposal , along with examples and templates to help you ace this step in your research journey.  

What is a Research Proposal ?  

A research proposal¹ ,²  can be defined as a formal report that describes your proposed research, its objectives, methodology, implications, and other important details. Research proposals are the framework of your research and are used to obtain approvals or grants to conduct the study from various committees or organizations. Consequently, research proposals should convince readers of your study’s credibility, accuracy, achievability, practicality, and reproducibility.   

With research proposals , researchers usually aim to persuade the readers, funding agencies, educational institutions, and supervisors to approve the proposal. To achieve this, the report should be well structured with the objectives written in clear, understandable language devoid of jargon. A well-organized research proposal conveys to the readers or evaluators that the writer has thought out the research plan meticulously and has the resources to ensure timely completion.  

Purpose of Research Proposals  

A research proposal is a sales pitch and therefore should be detailed enough to convince your readers, who could be supervisors, ethics committees, universities, etc., that what you’re proposing has merit and is feasible . Research proposals can help students discuss their dissertation with their faculty or fulfill course requirements and also help researchers obtain funding. A well-structured proposal instills confidence among readers about your ability to conduct and complete the study as proposed.  

Research proposals can be written for several reasons:³  

• To describe the importance of research in the specific topic  
• Address any potential challenges you may encounter  
• Showcase knowledge in the field and your ability to conduct a study  
• Apply for a role at a research institute  
• Convince a research supervisor or university that your research can satisfy the requirements of a degree program  
• Highlight the importance of your research to organizations that may sponsor your project  
• Identify implications of your project and how it can benefit the audience  

What Goes in a Research Proposal?    

Research proposals should aim to answer the three basic questions—what, why, and how.  

The What question should be answered by describing the specific subject being researched. It should typically include the objectives, the cohort details, and the location or setting.  

The Why question should be answered by describing the existing scenario of the subject, listing unanswered questions, identifying gaps in the existing research, and describing how your study can address these gaps, along with the implications and significance.  

The How question should be answered by describing the proposed research methodology, data analysis tools expected to be used, and other details to describe your proposed methodology.   

Research Proposal Example  

Here is a research proposal sample template (with examples) from the University of Rochester Medical Center. 4 The sections in all research proposals are essentially the same although different terminology and other specific sections may be used depending on the subject.  

Structure of a Research Proposal  

If you want to know how to make a research proposal impactful, include the following components:¹  

1. Introduction  

This section provides a background of the study, including the research topic, what is already known about it and the gaps, and the significance of the proposed research.  

2. Literature review  

This section contains descriptions of all the previous relevant studies pertaining to the research topic. Every study cited should be described in a few sentences, starting with the general studies to the more specific ones. This section builds on the understanding gained by readers in the Introduction section and supports it by citing relevant prior literature, indicating to readers that you have thoroughly researched your subject.  

3. Objectives  

Once the background and gaps in the research topic have been established, authors must now state the aims of the research clearly. Hypotheses should be mentioned here. This section further helps readers understand what your study’s specific goals are.  

4. Research design and methodology  

Here, authors should clearly describe the methods they intend to use to achieve their proposed objectives. Important components of this section include the population and sample size, data collection and analysis methods and duration, statistical analysis software, measures to avoid bias (randomization, blinding), etc.  

5. Ethical considerations  

This refers to the protection of participants’ rights, such as the right to privacy, right to confidentiality, etc. Researchers need to obtain informed consent and institutional review approval by the required authorities and mention this clearly for transparency.  

6. Budget/funding  

Researchers should prepare their budget and include all expected expenditures. An additional allowance for contingencies such as delays should also be factored in.  

7. Appendices  

This section typically includes information that supports the research proposal and may include informed consent forms, questionnaires, participant information, measurement tools, etc.  

8. Citations  

Important Tips for Writing a Research Proposal  

Writing a research proposal begins much before the actual task of writing. Planning the research proposal structure and content is an important stage, which if done efficiently, can help you seamlessly transition into the writing stage. 3,5  

The Planning Stage  

• Manage your time efficiently. Plan to have the draft version ready at least two weeks before your deadline and the final version at least two to three days before the deadline.
• What is the primary objective of your research?  
• Will your research address any existing gap?  
• What is the impact of your proposed research?  
• Do people outside your field find your research applicable in other areas?  
• If your research is unsuccessful, would there still be other useful research outcomes?  

  The Writing Stage  

• Create an outline with main section headings that are typically used.  
• Focus only on writing and getting your points across without worrying about the format of the research proposal , grammar, punctuation, etc. These can be fixed during the subsequent passes. Add details to each section heading you created in the beginning.   
• Ensure your sentences are concise and use plain language. A research proposal usually contains about 2,000 to 4,000 words or four to seven pages.  
• Don’t use too many technical terms and abbreviations assuming that the readers would know them. Define the abbreviations and technical terms.  
• Ensure that the entire content is readable. Avoid using long paragraphs because they affect the continuity in reading. Break them into shorter paragraphs and introduce some white space for readability.  
• Focus on only the major research issues and cite sources accordingly. Don’t include generic information or their sources in the literature review.  
• Proofread your final document to ensure there are no grammatical errors so readers can enjoy a seamless, uninterrupted read.  
• Use academic, scholarly language because it brings formality into a document.  
• Ensure that your title is created using the keywords in the document and is neither too long and specific nor too short and general.  
• Cite all sources appropriately to avoid plagiarism.  
• Make sure that you follow guidelines, if provided. This includes rules as simple as using a specific font or a hyphen or en dash between numerical ranges.  
• Ensure that you’ve answered all questions requested by the evaluating authority.  

Key Takeaways   

Here’s a summary of the main points about research proposals discussed in the previous sections:  

• A research proposal is a document that outlines the details of a proposed study and is created by researchers to submit to evaluators who could be research institutions, universities, faculty, etc.  
• Research proposals are usually about 2,000-4,000 words long, but this depends on the evaluating authority’s guidelines.  
• A good research proposal ensures that you’ve done your background research and assessed the feasibility of the research.  
• Research proposals have the following main sections—introduction, literature review, objectives, methodology, ethical considerations, and budget.  

Frequently Asked Questions  

Q1. How is a research proposal evaluated?  

A1. In general, most evaluators, including universities, broadly use the following criteria to evaluate research proposals . 6  

• Significance —Does the research address any important subject or issue, which may or may not be specific to the evaluator or university?  
• Content and design —Is the proposed methodology appropriate to answer the research question? Are the objectives clear and well aligned with the proposed methodology?  
• Sample size and selection —Is the target population or cohort size clearly mentioned? Is the sampling process used to select participants randomized, appropriate, and free of bias?  
• Timing —Are the proposed data collection dates mentioned clearly? Is the project feasible given the specified resources and timeline?  
• Data management and dissemination —Who will have access to the data? What is the plan for data analysis?  

Q2. What is the difference between the Introduction and Literature Review sections in a research proposal ?  

A2. The Introduction or Background section in a research proposal sets the context of the study by describing the current scenario of the subject and identifying the gaps and need for the research. A Literature Review, on the other hand, provides references to all prior relevant literature to help corroborate the gaps identified and the research need.  

Q3. How long should a research proposal be?  

A3. Research proposal lengths vary with the evaluating authority like universities or committees and also the subject. Here’s a table that lists the typical research proposal lengths for a few universities.  

Q4. What are the common mistakes to avoid in a research proposal ?  

A4. Here are a few common mistakes that you must avoid while writing a research proposal . 7  

• No clear objectives: Objectives should be clear, specific, and measurable for the easy understanding among readers.  
• Incomplete or unconvincing background research: Background research usually includes a review of the current scenario of the particular industry and also a review of the previous literature on the subject. This helps readers understand your reasons for undertaking this research because you identified gaps in the existing research.  
• Overlooking project feasibility: The project scope and estimates should be realistic considering the resources and time available.   
• Neglecting the impact and significance of the study: In a research proposal , readers and evaluators look for the implications or significance of your research and how it contributes to the existing research. This information should always be included.  
• Unstructured format of a research proposal : A well-structured document gives confidence to evaluators that you have read the guidelines carefully and are well organized in your approach, consequently affirming that you will be able to undertake the research as mentioned in your proposal.  
• Ineffective writing style: The language used should be formal and grammatically correct. If required, editors could be consulted, including AI-based tools such as Paperpal , to refine the research proposal structure and language.  

Thus, a research proposal is an essential document that can help you promote your research and secure funds and grants for conducting your research. Consequently, it should be well written in clear language and include all essential details to convince the evaluators of your ability to conduct the research as proposed.  

This article has described all the important components of a research proposal and has also provided tips to improve your writing style. We hope all these tips will help you write a well-structured research proposal to ensure receipt of grants or any other purpose.  

References  

• Sudheesh K, Duggappa DR, Nethra SS. How to write a research proposal? Indian J Anaesth. 2016;60(9):631-634. Accessed July 15, 2024. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037942/  
• Writing research proposals. Harvard College Office of Undergraduate Research and Fellowships. Harvard University. Accessed July 14, 2024. https://uraf.harvard.edu/apply-opportunities/app-components/essays/research-proposals  
• What is a research proposal? Plus how to write one. Indeed website. Accessed July 17, 2024. https://www.indeed.com/career-advice/career-development/research-proposal  
• Research proposal template. University of Rochester Medical Center. Accessed July 16, 2024. https://www.urmc.rochester.edu/MediaLibraries/URMCMedia/pediatrics/research/documents/Research-proposal-Template.pdf  
• Tips for successful proposal writing. Johns Hopkins University. Accessed July 17, 2024. https://research.jhu.edu/wp-content/uploads/2018/09/Tips-for-Successful-Proposal-Writing.pdf  
• Formal review of research proposals. Cornell University. Accessed July 18, 2024. https://irp.dpb.cornell.edu/surveys/survey-assessment-review-group/research-proposals  
• 7 Mistakes you must avoid in your research proposal. Aveksana (via LinkedIn). Accessed July 17, 2024. https://www.linkedin.com/pulse/7-mistakes-you-must-avoid-your-research-proposal-aveksana-cmtwf/  

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The top 100 papers.

Nature explores the most-cited research of all time.

• Richard Van Noorden ,

Brendan Maher

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The paper mountain

Take a trip through the most highly cited papers of all time

The discovery of high-temperature superconductors, the determination of DNA’s double-helix structure, the first observations that the expansion of the Universe is accelerating — all of these breakthroughs won Nobel prizes and international acclaim. Yet none of the papers that announced them comes anywhere close to ranking among the 100 most highly cited papers of all time.

Citations, in which one paper refers to earlier works, are the standard means by which authors acknowledge the source of their methods, ideas and findings, and are often used as a rough measure of a paper’s importance. Fifty years ago, Eugene Garfield published the Science Citation Index (SCI), the first systematic effort to track citations in the scientific literature. To mark the anniversary, Nature asked Thomson Reuters, which now owns the SCI, to list the 100 most highly cited papers of all time. (See the full list at Web of Science Top 100.xls or the interactive graphic , below.) The search covered all of Thomson Reuter’s Web of Science, an online version of the SCI that also includes databases covering the social sciences, arts and humanities, conference proceedings and some books. It lists papers published from 1900 to the present day.

 Richard van Noorden discusses what makes it to the top of the citation-count charts.

The exercise revealed some surprises, not least that it takes a staggering 12,119 citations to rank in the top 100 — and that many of the world’s most famous papers do not make the cut. A few that do, such as the first observation 1 of carbon nanotubes (number 36) are indeed classic discoveries. But the vast majority describe experimental methods or software that have become essential in their fields.

The most cited work in history, for example, is a 1951 paper 2 describing an assay to determine the amount of protein in a solution. It has now gathered more than 305,000 citations — a recognition that always puzzled its lead author, the late US biochemist Oliver Lowry. “Although I really know it is not a great paper … I secretly get a kick out of the response,” he wrote in 1977.

The colossal size of the scholarly literature means that the top-100 papers are extreme outliers. Thomson Reuter’s Web of Science holds some 58 million items. If that corpus were scaled to Mount Kilimanjaro, then the 100 most-cited papers would represent just 1 centimetre at the peak. Only 14,499 papers — roughly a metre and a half’s worth — have more than 1,000 citations (see ‘The paper mountain’ ). Meanwhile, the foothills comprise works that have been cited only once, if at all — a group that encompasses roughly half of the items.

This interactive graphic requires a modern browser (e.g. Chrome, Safari, Firefox or Internet Explorer 9+) with javascript enabled.

The Thomson Reuters top 100 cited papers can be downloaded here: Web of Science Top 100.xls

Click through to explore the Web of Science's all-time top-cited papers. (Data provided by Thomson Reuters, extracted on 7 October 2014).

Rank: Citations:

Discipline colour

Nobody fully understands what distinguishes the sliver at the top from papers that are merely very well known — but researchers’ customs explain some of it. Paul Wouters, director of the Centre for Science and Technology Studies in Leiden, the Netherlands, says that many methods papers “become a standard reference that one cites in order to make clear to other scientists what kind of work one is doing”. Another common practice in science ensures that truly foundational discoveries — Einstein’s special theory of relativity, for instance — get fewer citations than they might deserve: they are so important that they quickly enter the textbooks or are incorporated into the main text of papers as terms deemed so familiar that they do not need a citation.

Citation counts are riddled with other confounding factors. The volume of citations has increased, for example — yet older papers have had more time to accrue citations. Biologists tend to cite one another’s work more frequently than, say, physicists. And not all fields produce the same number of publications. Modern bibliometricians therefore recoil from methods as crude as simply counting citations when they want to measure a paper’s value: instead, they prefer to compare counts for papers of similar age, and in comparable fields.

Nor is Thomson Reuters’ list the only ranking system available. Google Scholar compiled its own top-100 list for Nature (see ‘An alternative ranking’ ). It is based on many more citations because the search engine culls references from a much greater (although poorly characterized) literature base, including from a large range of books. In that list, available at Google Scholar Top 100.xls , economics papers have more prominence. Google Scholar’s list also features books, which Thomson Reuters did not analyse. But among the science papers, many of the same titles show up.

Yet even with all the caveats, the old-fashioned hall of fame still has value. If nothing else, it serves as a reminder of the nature of scientific knowledge. To make exciting advances, researchers rely on relatively unsung papers to describe experimental methods, databases and software.

Here Nature tours some of the key methods that tens of thousands of citations have hoisted to the top of science’s Kilimanjaro — essential, but rarely thrust into the limelight.

Photo by Kyle Bean; Design by Wesley Fernandes/nature

Biological techniques

For decades, the top-100 list has been dominated by protein biochemistry. The 1951 paper 2 describing the Lowry method for quantifying protein remains practically unreachable at number 1, even though many biochemists say that it and the competing Bradford assay 3 — described by paper number 3 on the list — are a tad outdated. In between, at number 2, is Laemmli buffer 4 , which is used in a different kind of protein analysis. The dominance of these techniques is attributable to the high volume of citations in cell and molecular biology, where they remain indispensable tools.

At least two of the biological techniques described by top-100 papers have resulted in Nobel prizes. Number 4 on the list describes the DNA-sequencing method 5 that earned the late Frederick Sanger his share of the 1980 Nobel Prize in Chemistry. Number 63 describes polymerase chain reaction (PCR) 6 , a method for copying segments of DNA that earned US biochemist Kary Mullis the prize in 1993. By helping scientists to explore and manipulate DNA, both methods have helped to drive a revolution in genetic research that continues to this day.

Other methods have received less public acclaim, but are not without their rewards. In the 1980s, the Italian cancer geneticist Nicoletta Sacchi linked up with Polish molecular biologist Piotr Chomczynski in the United States to publish 7 a fast, inexpensive way to extract RNA from a biological sample. As it became wildly popular — currently, it is number 5 on the list — Chomczynski patented modifications on the technique and built a business out of selling the reagents. Now at the Roswell Park Cancer Institute in Buffalo, New York, Sacchi says that she received little in the way of monetary rewards, but takes satisfaction from seeing great discoveries built on her work. The technique played a part in the explosive growth in the study of short RNA molecules that do not code for protein, for example. “That is what I would consider, scientifically speaking, a great reward,” she says.

Bioinformatics

The rapid expansion of genetic sequencing since Sanger’s contribution has helped to boost the ranking of papers describing ways to analyse the sequences. A prime example is BLAST (Basic Local Alignment Search Tool), which for two decades has been a household name for biologists wanting to work out what genes and proteins do. Users simply have to open the program in a web browser and plug in a DNA, RNA or protein sequence. Within seconds, they will be shown related sequences from thousands of organisms — along with information about the function of those sequences and even links to relevant literature. So popular is BLAST that versions 8 , 9 of the program feature twice on the list, at spots 12 and 14.

But owing to the vagaries of citation habits, BLAST has been bumped down the list by Clustal, a complementary programme for aligning multiple sequences at once. Clustal allows researchers to describe the evolutionary relationships between sequences from different organisms, to find matches among seemingly unrelated sequences and to predict how a change at a specific point in a gene or protein might affect its function. A 1994 paper 10 describing ClustalW, a user-friendly version of the software, is currently number 10 on the list. A 1997 paper 11 on a later version called ClustalX is number 28.

The team that developed ClustalW, at the European Molecular Biology Laboratory in Heidelberg, Germany, had created the program to work on a personal computer, rather than a mainframe. But the software was transformed when Julie Thompson, a computer scientist from the private sector, joined the lab in 1991. “It was a program written by biologists; I’m trying to find a nice way to say that,” says Thompson, who is now at the Institute of Genetics and Molecular and Cellular Biology in Strasbourg, France. Thompson rewrote the program to ready it for the volume and complexity of the genome data being generated at the time, while also making it easier to use.

The teams behind BLAST and Clustal are competitive about the ranking of their papers. It is a friendly sort of competition, however, says Des Higgins, a biologist at University College Dublin, and a member of the Clustal team. “BLAST was a game-changer, and they’ve earned every citation that they get.”

Phylogenetics

Another field buoyed by the growth in genome sequencing is phylogenetics, the study of evolutionary relationships between species.

Number 20 on the list is a paper 12 that introduced the “neighbor-joining” method, a fast, efficient way of placing a large number of organisms into a phylogenetic tree according to some measure of evolutionary distance between them, such as genetic variation. It links related organisms together one pair at a time until a tree is resolved. Physical anthropologist Naruya Saitou helped to devise the technique when he joined Masatoshi Nei’s lab at the University of Texas in Houston in the 1980s to work on human evolution and molecular genetics, two fields that were starting to burst at the seams with information.

“We physical anthropologists were facing kind of the big data of that time,” says Saitou, now at Japan’s National Institute of Genetics in Mishima. The technique made it possible to devise trees from large data sets without eating up computer resources. (And, in a nice cross-fertilization within the top-100, Clustal’s algorithms use the same strategy.)

Number 41 on the list is a description 13 of how to apply statistics to phylogenies. In 1984, evolutionary biologist Joe Felsenstein of the University of Washington in Seattle adapted a statistical tool known as the bootstrap to infer the accuracy of different parts of an evolutionary tree. The bootstrap involves resampling data from a set many times over, then using the variation in the resulting estimates to determine the confidence for individual branches. Although the paper was slow to amass citations, it rapidly grew in popularity in the 1990s and 2000s as molecular biologists recognized the need to attach such intervals to their predictions.

Felsenstein says that the concept of the bootstrap 14 , devised in 1979 by Bradley Efron, a statistician at Stanford University in California, was much more fundamental than his work. But applying the method to a biological problem means it is cited by a much larger pool of researchers. His high citation count is also a consequence of how busy he was at the time, he says: he crammed everything into one paper rather than publishing multiple papers on the topic, which might have diluted the number of citations each one received. “I was unable to go off and write four more papers on the same thing,” he says. “I was too swamped to do that, not too principled.”

Although the top-100 list has a rich seam of papers on statistics, says Stephen Stigler, a statistician at the University of Chicago in Illinois and an expert on the history of the field, “these papers are not at all those that have been most important to us statisticians”. Rather, they are the ones that have proved to be most useful to the vastly larger population of practising scientists.

Much of this crossover success stems from the ever-expanding stream of data coming out of biomedical labs. For example, the most frequently cited statistics paper (number 11) is a 1958 publication 15 by US statisticians Edward Kaplan and Paul Meier that helps researchers to find survival patterns for a population, such as participants in clinical trials. That introduced what is now known as the Kaplan–Meier estimate. The second (number 24) was British statistician David Cox’s 1972 paper 16 that expanded these survival analyses to include factors such as gender and age.

The Kaplan–Meier paper was a sleeper hit, receiving almost no citations until computing power boomed in the 1970s, making the methods accessible to non-specialists. Simplicity and ease of use also boosted the popularity of papers in this field. British statisticians Martin Bland and Douglas Altman made the list (number 29) with a technique 17 — now known as the Bland–Altman plot — for visualizing how well two measurement methods agree. The same idea had been introduced by another statistician 14 years earlier, but Bland and Altman presented it in an accessible way that has won citations ever since.

The oldest and youngest papers in the statistics group deal with the same problem — multiple comparisons of data — but from very different scientific milieux. US statistician David Duncan’s 1955 paper 18 (number 64) is useful when a few groups need to be compared. But at number 59, Israeli statisticians Yoav Benjamini and Yosef Hochberg’s 1995 paper 19 on controlling the false-discovery rate is ideally suited for data coming from fields such as genomics or neuroscience imaging, in which comparisons number in the hundreds of thousands — a scale that Duncan could hardly have imagined. As Efron observes: “The story is one of the computer slowly, then not so slowly, making its influence felt on statistical theory as well as on practice.”

An alternative ranking

The Web of Science is not the only index of citations available. Google Scholar has also generated a list of the ‘most-cited’ articles of all time for Nature ( Google Scholar Top 100.xls ). Two-thirds of the entries are books, which Thomson Reuters did not include. “Folks have focused on journals, but there is this other world of books out there,” says Anurag Acharya, a software engineer who leads the Google Scholar team in Mountain View, California. At number 4, the most-cited book is the manual Molecular Cloning , a mainstay of molecular-biology laboratories. But the list shows that research articles can be just as influential as books, notes Acharya. And at the top of both Google’s and Thomson Reuters’ rankings are the same three research articles — albeit in different order.

A separate Google Scholar top 100 showing only the top-cited research articles ( Google Scholar Top 100 articles only.xls ) throws up many similar papers to the Web of Science ranking. Noticeably, however, just over one-third of the list is different, with economics and psychology articles making considerable inroads, perhaps because they gain more citations from books than do other fields. Number 21, for example — a 1976 article on managerial behaviour in firms ( M. C. Jensen & W. H. Meckling J. Financ. Econ. 3, 305–360; 1976 ) — received 45,119 citations in Google’s list, but just 8,372 in Web of Science. (Google gives most documents a higher number of citations than Web of Science, but a 5-fold difference is unusual). Highest of the Google Scholar new entrants, at number 4 in the list, is Claude Shannon’s 1948 paper that birthed modern information theory ( C. E. Shannon Bell Syst. Tech. J . 27, 379–423; 1948 ). Google Scholar credits that with 69,273 citations, while the Web of Science gives it 10,239 citations — so just misses out on the top 100.

The Google Scholar top-10 list of articles with books interspersed

*Book not included in Web of Science. Nature could not find exact matches to all of the documents or books that Google Scholar recorded as heavily cited. The data are provided as received from Google Scholar.

Density functional theory

When theorists want to model a piece of matter — be it a drug molecule or a slab of metal — they often use software to calculate the behaviour of the material’s electrons. From this knowledge flows an understanding of numerous other properties: a protein’s reactivity, for instance, or how easily Earth’s liquid iron outer core conducts heat.

Most of this software is built on density functional theory (DFT), easily the most heavily cited concept in the physical sciences. Twelve papers on the top-100 list relate to it, including 2 of the top 10. At its heart, DFT is an approximation that makes impossible mathematics easy, says Feliciano Giustino, a materials physicist at the University of Oxford, UK. To study electronic behaviour in a silicon crystal by taking account of how every electron and every nucleus interacts with every other electron and nucleus, a researcher would need to analyse one sextillion (10 21 ) terabytes of data, he says — far beyond the capacity of any conceivable computer. DFT reduces the data requirement to just a few hundred kilobytes, well within the capacity of a standard laptop.

Theoretical physicist Walter Kohn led the development of DFT half a century ago in papers 20 , 21 that now rank as numbers 34 and 39. Kohn realized that he could calculate a system’s properties, such as its lowest energy state, by assuming that each electron reacts to all the others not as individuals, but as a smeared-out average. In principle, the mathematics are straightforward: the system behaves like a continuous fluid with a density that varies from point to point. Hence the theory’s name.

But a few decades passed before researchers found ways to implement the idea for real materials, says Giustino. Two 22 , 23 top-100 papers are technical recipes on which the most popular DFT methods and software packages are built. One (number 8) is by Axel Becke, a theoretical chemist at Dalhousie University in Halifax, Canada, and the other (number 7) is by US-based theoretical chemists Chengteh Lee, Weitao Yang and Robert Parr. In 1992, computational chemist John Pople (who would share the 1998 Nobel prize with Kohn) included a form of DFT in his popular Gaussian software package.

Software users probably cite the original theoretical papers even if they do not fully understand the theory, says Becke. “The theory, mathematics and computer software are specialized and are the concern of quantum physicists and chemists,” he says. “But the applications are endless. At a fundamental level, DFT can be used to describe all of chemistry, biochemistry, biology, nanosystems and materials. Everything in our terrestrial world depends on the motions of electrons — therefore, DFT literally underlies everything.”

Crystallography

George Sheldrick, a chemist at the University of Göttingen in Germany, began to write software to help solve crystal structures in the 1970s. In those days, he says, “you couldn’t get grant money for that kind of project. My job was to teach chemistry, and I wrote the programs as a hobby in my spare time.” But over 40 years, his work gave rise to the regularly updated SHELX suite of computer programs, which has become one of the most popular tools for analysing the scattering patterns of X-rays that are shot through a crystal — thereby revealing the atomic structure.

The extent of that popularity became apparent after 2008, when Sheldrick published a review paper 24 about the history of the system, and noted that it might serve as a general literature citation whenever any of the SHELX programs were used. Readers followed his advice. In the past 6 years, that review paper has amassed almost 38,000 citations, catapulting it to number 13 and making it the highest-ranked paper published in the past two decades.

The top-100 list is scattered with other tools essential to crystallography and structural biology. These include papers describing the HKL suite 25 (number 23) for analysing X-ray diffraction data; the PROCHECK programs 26 (number 71) used to analyse whether a proposed protein structure seems geometrically normal or outlandish; and two programs 27 , 28 used to sketch molecular structures (numbers 82 and 95). These tools are the “bricks and mortar” for determining crystal structures, says Philip Bourne, associate director for data science at the US National Institutes of Health in Bethesda, Maryland.

An unusual entry, appearing at number 22, is a 1976 paper 29 from Robert Shannon — a researcher at the giant chemical firm DuPont in Wilmington, Delaware, who compiled a comprehensive list of the radii of ions in a series of different materials. Robin Grimes, a materials scientist at Imperial College London, says that physicists, chemists and theorists still cite this paper when they look up values of ionic size, which often correlate neatly with other properties of a substance. This has made it the highest formally-cited database of all time.

“We often cite these kinds of papers almost without thinking about it,” says Paul Fossati, one of Grimes’s research colleagues. The same could be said for many of the methods and databases in the top 100. The list reveals just how powerfully research has been affected by computation and the analysis of large data sets. But it also serves as a reminder that the position of any particular methods paper or database at the top of the citation charts is also down to luck and circumstance.

Still, there is one powerful lesson for researchers, notes Peter Moore, a chemist at Yale University in New Haven, Connecticut. “If citations are what you want,” he says, “devising a method that makes it possible for people to do the experiments they want at all, or more easily, will get you a lot further than, say, discovering the secret of the Universe”.

• See Comment page 561

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Bradford, M. M. Anal. Biochem. 72 , 248 – 254 ( 1976 ).

Laemmli, U. K. Nature 227 , 680 – 685 ( 1970 ).

Sanger. F., Nicklen, S. & Couslon, A. R. Proc. Natl Acad. Sci. USA 74 , 5463 – 5467 ( 1977 ).

Saiki, R. K. et al . Science 239 , 487 – 491 ( 1988 ).

Chomczynski, P. & Sacchi, N. Anal. Biochem. 162 , 156 – 159 ( 1987 ).

Altschul, S. F. , Gish, W. , Miller, W. , Myers, E. W. & Lipman, D. J. J. Mol. Biol. 215 , 403 – 410 ( 1990 ).

Altschul, S. F. et al . Nucleic Acids Res. 25 , 3389 – 3402 ( 1997 ).

Thompson, J. D. , Higgins, D. G. & Gibson, T. J. Nucleic Acids Res. 22 , 4673 – 4680 ( 1994 ).

Thompson, J. D. , Gibson, T. J. , Plewniak, F. , Jeanmougin, F. & Higgins, D. G. Nucleic Acids Res. 25 , 4876 – 4882 ( 1997 ).

Saitou, N. & Nei, M. Mol. Biol. Evol. 4 , 406 – 425 ( 1987 ).

Felsenstein, J. Evolution 39 , 783 – 791 ( 1985 ).

Efron, B. Ann. Statist. 7 , 1 – 26 ( 1979 ).

Kaplan, E. L. & Meier, P. J. Am. Stat. Assoc. 53 , 457 – 481 ( 1958 ).

Cox, D. R. J. R. Stat. Soc. B 34 , 187 – 220 ( 1972 ).

Bland, J. M. & Altman, D. G. Lancet 327 , 307 – 310 ( 1986 ).

Duncan, D. B. Biometrics 11 , 1 – 42 ( 1955 ).

Benjamini, Y. & Hochberg, Y. J. R. Stat. Soc. B 57 , 289 – 300 ( 1995 ).

Kohn, W. & Sham, L. J. Phys. Rev. 140 , A1133 ( 1965 ).

Hohenberg, P. & Kohn, W. Phys. Rev. B 136 , B864 ( 1964 ).

Becke, A. D. J. Chem. Phys. 98 , 5648 – 5652 ( 1993 ).

Lee. C., Yang, W. & Parr, R. G. Phys. Rev. B 37 , 785 – 789 ( 1988 ).

Sheldrick, G. M. Acta Crystallogr. A 64 , 112 – 122 ( 2008 ).

Otwinowski, Z. & Minor, W. Method. Enzymol. A 276 , 307 – 326 ( 1997 ).

Laskowski, R. A. , MacArthur, M. W. , Moss, D. S. & Thornton, J. M. J. Appl. Crystallogr. 26 , 283 – 291 ( 1993 ).

Kraulis, P. J. J. Appl. Crystallogr. 24 , 946 – 950 (1991).

Jones, T. A. , Zou, J.-Y. , Cowan, S. W. & Kjeldgaard, M. Acta Crystallogr. A 47 , 110 – 119 ( 1991 ).

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What Is a Research Paper?

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A research paper is a common form of academic writing . Research papers require students and academics to locate information about a topic (that is, to conduct research ), take a stand on that topic, and provide support (or evidence) for that position in an organized report.

The term research paper may also refer to a scholarly article that contains the results of original research or an evaluation of research conducted by others. Most scholarly articles must undergo a process of peer review before they can be accepted for publication in an academic journal.

Define Your Research Question

The first step in writing a research paper is defining your research question . Has your instructor assigned a specific topic? If so, great—you've got this step covered. If not, review the guidelines of the assignment. Your instructor has likely provided several general subjects for your consideration. Your research paper should focus on a specific angle on one of these subjects. Spend some time mulling over your options before deciding which one you'd like to explore more deeply.

Try to choose a research question that interests you. The research process is time-consuming, and you'll be significantly more motivated if you have a genuine desire to learn more about the topic. You should also consider whether you have access to all of the resources necessary to conduct thorough research on your topic, such as primary and secondary sources .

Create a Research Strategy 

Approach the research process systematically by creating a research strategy. First, review your library's website. What resources are available? Where will you find them? Do any resources require a special process to gain access? Start gathering those resources—especially those that may be difficult to access—as soon as possible.

Second, make an appointment with a reference librarian . A reference librarian is nothing short of a research superhero. He or she will listen to your research question, offer suggestions for how to focus your research, and direct you toward valuable sources that directly relate to your topic.

Evaluate Sources

Now that you've gathered a wide array of sources, it's time to evaluate them. First, consider the reliability of the information. Where is the information coming from? What is the origin of the source? Second, assess the  relevance  of the information. How does this information relate to your research question? Does it support, refute, or add context to your position? How does it relate to the other sources you'll be using in your paper? Once you have determined that your sources are both reliable and relevant, you can proceed confidently to the writing phase. 

Why Write Research Papers? 

The research process is one of the most taxing academic tasks you'll be asked to complete. Luckily, the value of writing a research paper goes beyond that A+ you hope to receive. Here are just some of the benefits of research papers. 

• Learning Scholarly Conventions:  Writing a research paper is a crash course in the stylistic conventions of scholarly writing. During the research and writing process, you'll learn how to document your research, cite sources appropriately, format an academic paper, maintain an academic tone, and more.
• Organizing Information: In a way, research is nothing more than a massive organizational project. The information available to you is near-infinite, and it's your job to review that information, narrow it down, categorize it, and present it in a clear, relevant format. This process requires attention to detail and major brainpower.
• Managing Time: Research papers put your time management  skills to the test. Every step of the research and writing process takes time, and it's up to you to set aside the time you'll need to complete each step of the task. Maximize your efficiency by creating a research schedule and inserting blocks of "research time" into your calendar as soon as you receive the assignment. 
• Exploring Your Chosen Subject:  We couldn't forget the best part of research papers—learning about something that truly excites you. No matter what topic you choose, you're bound to come away from the research process with new ideas and countless nuggets of fascinating information. 

The best research papers are the result of genuine interest and a thorough research process. With these ideas in mind, go forth and research. Welcome to the scholarly conversation!

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Massive biomolecular shifts occur in our 40s and 60s, Stanford Medicine researchers find

Time marches on predictably, but biological aging is anything but constant, according to a new Stanford Medicine study.

August 14, 2024 - By Rachel Tompa

We undergo two periods of rapid change, averaging around age 44 and age 60, according to a Stanford Medicine study. Ratana21 /Shutterstock.com

If it’s ever felt like everything in your body is breaking down at once, that might not be your imagination. A new Stanford Medicine study shows that many of our molecules and microorganisms dramatically rise or fall in number during our 40s and 60s.

Researchers assessed many thousands of different molecules in people from age 25 to 75, as well as their microbiomes — the bacteria, viruses and fungi that live inside us and on our skin — and found that the abundance of most molecules and microbes do not shift in a gradual, chronological fashion. Rather, we undergo two periods of rapid change during our life span, averaging around age 44 and age 60. A paper describing these findings was published in the journal Nature Aging Aug. 14.

“We’re not just changing gradually over time; there are some really dramatic changes,” said Michael Snyder , PhD, professor of genetics and the study’s senior author. “It turns out the mid-40s is a time of dramatic change, as is the early 60s. And that’s true no matter what class of molecules you look at.”

Xiaotao Shen, PhD, a former Stanford Medicine postdoctoral scholar, was the first author of the study. Shen is now an assistant professor at Nanyang Technological University Singapore.

These big changes likely impact our health — the number of molecules related to cardiovascular disease showed significant changes at both time points, and those related to immune function changed in people in their early 60s.

Abrupt changes in number

Snyder, the Stanford W. Ascherman, MD, FACS Professor in Genetics, and his colleagues were inspired to look at the rate of molecular and microbial shifts by the observation that the risk of developing many age-linked diseases does not rise incrementally along with years. For example, risks for Alzheimer’s disease and cardiovascular disease rise sharply in older age, compared with a gradual increase in risk for those under 60.

The researchers used data from 108 people they’ve been following to better understand the biology of aging. Past insights from this same group of study volunteers include the discovery of four distinct “ ageotypes ,” showing that people’s kidneys, livers, metabolism and immune system age at different rates in different people.

Michael Snyder

The new study analyzed participants who donated blood and other biological samples every few months over the span of several years; the scientists tracked many different kinds of molecules in these samples, including RNA, proteins and metabolites, as well as shifts in the participants’ microbiomes. The researchers tracked age-related changes in more than 135,000 different molecules and microbes, for a total of nearly 250 billion distinct data points.

They found that thousands of molecules and microbes undergo shifts in their abundance, either increasing or decreasing — around 81% of all the molecules they studied showed non-linear fluctuations in number, meaning that they changed more at certain ages than other times. When they looked for clusters of molecules with the largest changes in amount, they found these transformations occurred the most in two time periods: when people were in their mid-40s, and when they were in their early 60s.

Although much research has focused on how different molecules increase or decrease as we age and how biological age may differ from chronological age, very few have looked at the rate of biological aging. That so many dramatic changes happen in the early 60s is perhaps not surprising, Snyder said, as many age-related disease risks and other age-related phenomena are known to increase at that point in life.

The large cluster of changes in the mid-40s was somewhat surprising to the scientists. At first, they assumed that menopause or perimenopause was driving large changes in the women in their study, skewing the whole group. But when they broke out the study group by sex, they found the shift was happening in men in their mid-40s, too.

“This suggests that while menopause or perimenopause may contribute to the changes observed in women in their mid-40s, there are likely other, more significant factors influencing these changes in both men and women. Identifying and studying these factors should be a priority for future research,” Shen said.

Changes may influence health and disease risk

In people in their 40s, significant changes were seen in the number of molecules related to alcohol, caffeine and lipid metabolism; cardiovascular disease; and skin and muscle. In those in their 60s, changes were related to carbohydrate and caffeine metabolism, immune regulation, kidney function, cardiovascular disease, and skin and muscle.

It’s possible some of these changes could be tied to lifestyle or behavioral factors that cluster at these age groups, rather than being driven by biological factors, Snyder said. For example, dysfunction in alcohol metabolism could result from an uptick in alcohol consumption in people’s mid-40s, often a stressful period of life.

The team plans to explore the drivers of these clusters of change. But whatever their causes, the existence of these clusters points to the need for people to pay attention to their health, especially in their 40s and 60s, the researchers said. That could look like increasing exercise to protect your heart and maintain muscle mass at both ages or decreasing alcohol consumption in your 40s as your ability to metabolize alcohol slows.

“I’m a big believer that we should try to adjust our lifestyles while we’re still healthy,” Snyder said.

The study was funded by the National Institutes of Health (grants U54DK102556, R01 DK110186-03, R01HG008164, NIH S10OD020141, UL1 TR001085 and P30DK116074) and the Stanford Data Science Initiative.

• Rachel Tompa Rachel Tompa is a freelance science writer.

About Stanford Medicine

Stanford Medicine is an integrated academic health system comprising the Stanford School of Medicine and adult and pediatric health care delivery systems. Together, they harness the full potential of biomedicine through collaborative research, education and clinical care for patients. For more information, please visit med.stanford.edu .

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Title: the ai scientist: towards fully automated open-ended scientific discovery.

Abstract: One of the grand challenges of artificial general intelligence is developing agents capable of conducting scientific research and discovering new knowledge. While frontier models have already been used as aides to human scientists, e.g. for brainstorming ideas, writing code, or prediction tasks, they still conduct only a small part of the scientific process. This paper presents the first comprehensive framework for fully automatic scientific discovery, enabling frontier large language models to perform research independently and communicate their findings. We introduce The AI Scientist, which generates novel research ideas, writes code, executes experiments, visualizes results, describes its findings by writing a full scientific paper, and then runs a simulated review process for evaluation. In principle, this process can be repeated to iteratively develop ideas in an open-ended fashion, acting like the human scientific community. We demonstrate its versatility by applying it to three distinct subfields of machine learning: diffusion modeling, transformer-based language modeling, and learning dynamics. Each idea is implemented and developed into a full paper at a cost of less than $15 per paper. To evaluate the generated papers, we design and validate an automated reviewer, which we show achieves near-human performance in evaluating paper scores. The AI Scientist can produce papers that exceed the acceptance threshold at a top machine learning conference as judged by our automated reviewer. This approach signifies the beginning of a new era in scientific discovery in machine learning: bringing the transformative benefits of AI agents to the entire research process of AI itself, and taking us closer to a world where endless affordable creativity and innovation can be unleashed on the world's most challenging problems. Our code is open-sourced at this https URL

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How China Built Tech Prowess: Chemistry Classes and Research Labs

Stressing science education, China is outpacing other countries in research fields like battery chemistry, crucial to its lead in electric vehicles.

By Keith Bradsher

Reporting from Changsha, Beijing and Fuzhou, China

China’s domination of electric cars, which is threatening to start a trade war, was born decades ago in university laboratories in Texas, when researchers discovered how to make batteries with minerals that were abundant and cheap.

Companies from China have recently built on those early discoveries, figuring out how to make the batteries hold a powerful charge and endure more than a decade of daily recharges. They are inexpensively and reliably manufacturing vast numbers of these batteries, producing most of the world’s electric cars and many other clean energy systems.

Batteries are just one example of how China is catching up with — or passing — advanced industrial democracies in its technological and manufacturing sophistication. It is achieving many breakthroughs in a long list of sectors, from pharmaceuticals to drones to high-efficiency solar panels.

Beijing’s challenge to the technological leadership that the United States has held since World War II is evidenced in China’s classrooms and corporate budgets, as well as in directives from the highest levels of the Communist Party.

A considerably larger share of Chinese students major in science, math and engineering than students in other big countries do. That share is rising further, even as overall higher education enrollment has increased more than tenfold since 2000.

Spending on research and development has surged, tripling in the past decade and moving China into second place after the United States. Researchers in China lead the world in publishing widely cited papers in 52 of 64 critical technologies, recent calculations by the Australian Strategic Policy Institute reveal.

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