(PDF) Newer antidepressants for the treatment of depression in adults
(PDF) Depression, antidepressants and suicidality: A critical appraisal
(PDF) Antidepressants for depression in stage 3-5 chronic kidney
(PDF) Prevalence and Prescription of Antidepressants in Depression with
(PDF) Antidepressants for treatment of depression in primary care: A
(PDF) Antidepressants for depression after concussion and traumatic
VIDEO
Rethinking the Treatment of Depression: Have We Been Misinformed About Antidepressants?
ВШЭ 2020 доклад студента: антидепрессанты и их экономика
COMMENTS
Use of Antidepressants among Patients Diagnosed with Depression: A Scoping Review
1. Introduction. Depression is a common mental disorder and a major cause of functional disability [1, 2].According to the World Health Organization (WHO), by 2020, it will be the second-highest known cause of worldwide disability [3, 4].Depression is characterized by a sad mood, pessimistic thought, lowered interest in day-to-day activities, poor concentration, insomnia or increased sleep ...
Major depressive disorder: Validated treatments and future challenges
Depression is a prevalent psychiatric disorder that often leads to poor quality of life and impaired functioning. Treatment during the acute phase of a major depressive episode aims to help the patient reach a remission state and eventually return to their baseline level of functioning. Pharmacotherapy, especially selective serotonin reuptake ...
Treatment outcomes for depression: challenges and opportunities
Our lack of knowledge cannot be put down to a scarcity of research in existing treatments. In the past decades, more than 500 randomised trials have examined the effects of antidepressant medications, and more than 600 trials have examined the effects of psychotherapies for depression (although comparatively few are conducted for early-onset depression).
The drugs don't work? antidepressants and the current and future
Depression is a potentially life-threatening disorder affecting millions of people across the globe. It is a huge burden to both the individual and society, costing over £9 billion in 2000 alone: the World Health Organisation (WHO) cited it as the third leading cause of global disability in 2004 (first in the developed world), and project it will be the leading cause by 2030.
Comparative efficacy and acceptability of 21 antidepressant drugs for
All antidepressants were more efficacious than placebo in adults with major depressive disorder. Smaller differences between active drugs were found when placebo-controlled trials were included in the analysis, whereas there was more variability in efficacy and acceptability in head-to-head trials. These results should serve evidence-based practice and inform patients, physicians, guideline ...
The serotonin theory of depression: a systematic umbrella ...
The idea that depression is the result of abnormalities in brain chemicals, particularly serotonin (5-hydroxytryptamine or 5-HT), has been influential for decades, and provides an important ...
Antidepressants for the treatment of adults with major ...
A systematic review and random-effects model network meta-analysis were conducted to compare the efficacy, acceptability, tolerability, and safety of antidepressants to treat adults with major ...
Antidepressant side effects and their impact on treatment ...
Previous studies suggest that frequency, intensity, and burden of side effects are impacted by antidepressant treatment type, anxiety symptoms, and the presence of anxious depression (for a review ...
Major Depressive Disorder: Advances in Neuroscience Research and
Analysis of Published Papers. In the past decade, the total number of papers on depression published worldwide has increased year by year as shown in Fig. 1A. Searching the Web of Science database, we found a total of 43,863 papers published in the field of depression from 2009 to 2019 (search strategy: TI = (depression$) or ts = ("major depressive disorder$")) and py = (2009-2019), Articles).
How effective are antidepressants for depression over the long term? A
Treatment guidelines like those published by National Institute for Health and Care Excellence (NICE) or the American Psychiatric Association (APA) strongly recommend long-term maintenance treatment in people with (or at risk of) recurrent depression to prevent relapses. 1,2 In accordance with these recommendations, the rate and duration of antidepressant use is steadily increasing in the ...
The neuroscience of depressive disorders: A brief review of the past
Based on this short overview, we have then identified three potential lines of future scientific enquiry: first, the development of an integrated neuroscientific model of depression (and antidepressant treatment) that provides mechanistic links between abnormalities (and the effects of antidepressant interventions) on different levels of ...
Application of antidepressants in depression: A systematic ...
Information on study characteristics, depression or depressive symptoms, antidepressants and the descriptive statistics (including efficacy and safety of antidepressants) was extracted independently by 2 investigators. Estimates were pooled using random-effects meta-analysis. Differences by study-level characteristics were estimated using ...
Application of antidepressants in depression: A ...
Discussion. In this meta -analysis, we systematically summarize the effectiveness and side effects of different types of antidepressants. For the clinical efficacy and side effects of first-line antidepressants, anti-inflammatory drugs and ketamine, this article covers a comprehensive analysis.
Biological, Psychological, and Social Determinants of Depression: A
This review may be used as an evidence base by those in public health, clinical practice, and research. This paper discusses key areas in depression research; however, an exhaustive discussion of all the risk factors and determinants linked to depression and their mechanisms is not possible in one journal article—which, by its very nature, a ...
Antidepressants or running therapy: Comparing effects ...
Research paper. Antidepressants or running therapy: Comparing effects on mental and physical health in patients with depression and anxiety disorders ... Impact of depression and antidepressant treatment on heart rate variability: a review and meta-analysis. Biol. Psychiatry, 67 (2010), pp. 1067-1074. View PDF View article View in Scopus Google ...
Comparative effectiveness of antidepressants on geriatric depression
1. Introduction. Depression is a common disorder in late life that can reduce quality of life, and increase disability and all-cause mortality (Craig Nelson, 2019).For people over 55, the average prevalence of depression was estimated to be 13, and 2% of these people were found to have major depression (Beekman et al., 1999).Antidepressant agents are currently one important option for treating ...
The trouble with antidepressants: why the evidence overplays benefits
Widespread prescribing has not reduced mental disability or suicide, raising questions about the assessment of evidence on effectiveness and safety of antidepressants, writes John Warren Depression can be severe and reduce life expectancy. Antidepressant prescribing has increased substantially in recent years so that one in eight UK adults, some 7.3 million people, now receive a prescription ...
Depression articles: The New England Journal of Medicine
D.C. Steffens. N Engl J Med 2024;390:630-639. Treatment-resistant depression in older adults is common and can be difficult to manage. Strategies include ensuring adequate antidepressant therapy ...
Frontiers
The second edition of the e-book "The pharmacotherapy of depression-searching for new mechanisms and drug interactions" includes research and review papers. Three Reviews present the mechanisms of autophagy, ferroptosis, and mitophagy as a new strategy for treating depression (Lv et al.; Zhang et al.; Xu et al., respectively).Autophagy is a crucial mechanism of intracellular degradation ...
The complex clinical response to selective serotonin reuptake ...
The clinical response to selective serotonin reuptake inhibitors (SSRIs) in depression takes weeks to be fully developed [].While it has been suggested that initial improvements in mood, or ...
PDF Depression
Depression (also called major depression, major depressive disorder, or clinical depression) is diferent. It can cause severe symptoms that afect how a person feels, thinks, and handles daily activities, such as sleeping, eating, or working. Depression can afect anyone regardless of age, gender, race or ethnicity, income, culture, or education.
Gepirone Finally Gets FDA OK as Depression Treatment
In that randomized trial of over 200 participants with depression, adults who took gepirone on average experienced a 9.04-point decrease in the 17-item Hamilton Depression Rating Scale (HAMD-17) after eight weeks, compared with a 6.75-point decrease among adults who took placebo. These findings were not enough to convince the FDA, which in 2002 ...
How effective are antidepressants for depression over the long term? A
Introduction. Treatment guidelines like those published by National Institute for Health and Care Excellence (NICE) or the American Psychiatric Association (APA) strongly recommend long-term maintenance treatment in people with (or at risk of) recurrent depression to prevent relapses. 1,2 In accordance with these recommendations, the rate and duration of antidepressant use is steadily ...
Pressure grows to ditch controversial forced swim test in rodent ...
It seemed to work: Antidepressants and electroconvulsive therapy often made the animal try harder. The test remains popular, appearing in about 600 papers per year. But researchers have recently begun to question the assumption that the test really gauges depression and is a good predictor of human responses to drugs.
The fear of depression recurrence is potent but not universal, research
More information: Stephanie T. Gumuchian et al, Fear of depression recurrence among individuals with remitted depression: a qualitative interview study, BMC Psychiatry (2024). DOI: 10.1186/s12888 ...
Treating anxiety, depression in people with heart ...
Treating anxiety and depression reduced emergency room visits and rehospitalizations among people with heart disease, according to new research published today in the Journal of the American Heart ...
An in-depth analysis of four classes of antidepressants ...
Depression is a growing global crisis, with females at a higher rate of diagnosis than males. While the percentage of patients on prescribed antidepressants have tripled over the last two decades ...
Why depression goes undetected in teen boys: Doctors warn about symptoms
March 17, 2024, 3:00 AM PDT. By Erika Edwards. Teenage boys are drowning in just as much of the depression and anxiety that's been well documented in girls. Experts warn that many young men ...
Study Links Untreated Depression With Development of Dementia
A new study in Biological Psychiatry finds that treating depression may significantly reduce the later risk of developing dementia. The research suggests both antidepressants and psychotherapy can ...
Major Depressive Disorder: Advances in Neuroscience Research and
Analysis of Published Papers. In the past decade, the total number of papers on depression published worldwide has increased year by year as shown in Fig. Fig.1A. 1 A. Searching the Web of Science database, we found a total of 43,863 papers published in the field of depression from 2009 to 2019 (search strategy: TI = (depression$) or ts = ("major depressive disorder$")) and py = (2009-2019 ...
IMAGES
VIDEO
COMMENTS
1. Introduction. Depression is a common mental disorder and a major cause of functional disability [1, 2].According to the World Health Organization (WHO), by 2020, it will be the second-highest known cause of worldwide disability [3, 4].Depression is characterized by a sad mood, pessimistic thought, lowered interest in day-to-day activities, poor concentration, insomnia or increased sleep ...
Depression is a prevalent psychiatric disorder that often leads to poor quality of life and impaired functioning. Treatment during the acute phase of a major depressive episode aims to help the patient reach a remission state and eventually return to their baseline level of functioning. Pharmacotherapy, especially selective serotonin reuptake ...
Our lack of knowledge cannot be put down to a scarcity of research in existing treatments. In the past decades, more than 500 randomised trials have examined the effects of antidepressant medications, and more than 600 trials have examined the effects of psychotherapies for depression (although comparatively few are conducted for early-onset depression).
Depression is a potentially life-threatening disorder affecting millions of people across the globe. It is a huge burden to both the individual and society, costing over £9 billion in 2000 alone: the World Health Organisation (WHO) cited it as the third leading cause of global disability in 2004 (first in the developed world), and project it will be the leading cause by 2030.
All antidepressants were more efficacious than placebo in adults with major depressive disorder. Smaller differences between active drugs were found when placebo-controlled trials were included in the analysis, whereas there was more variability in efficacy and acceptability in head-to-head trials. These results should serve evidence-based practice and inform patients, physicians, guideline ...
The idea that depression is the result of abnormalities in brain chemicals, particularly serotonin (5-hydroxytryptamine or 5-HT), has been influential for decades, and provides an important ...
A systematic review and random-effects model network meta-analysis were conducted to compare the efficacy, acceptability, tolerability, and safety of antidepressants to treat adults with major ...
Previous studies suggest that frequency, intensity, and burden of side effects are impacted by antidepressant treatment type, anxiety symptoms, and the presence of anxious depression (for a review ...
Analysis of Published Papers. In the past decade, the total number of papers on depression published worldwide has increased year by year as shown in Fig. 1A. Searching the Web of Science database, we found a total of 43,863 papers published in the field of depression from 2009 to 2019 (search strategy: TI = (depression$) or ts = ("major depressive disorder$")) and py = (2009-2019), Articles).
Treatment guidelines like those published by National Institute for Health and Care Excellence (NICE) or the American Psychiatric Association (APA) strongly recommend long-term maintenance treatment in people with (or at risk of) recurrent depression to prevent relapses. 1,2 In accordance with these recommendations, the rate and duration of antidepressant use is steadily increasing in the ...
Based on this short overview, we have then identified three potential lines of future scientific enquiry: first, the development of an integrated neuroscientific model of depression (and antidepressant treatment) that provides mechanistic links between abnormalities (and the effects of antidepressant interventions) on different levels of ...
Information on study characteristics, depression or depressive symptoms, antidepressants and the descriptive statistics (including efficacy and safety of antidepressants) was extracted independently by 2 investigators. Estimates were pooled using random-effects meta-analysis. Differences by study-level characteristics were estimated using ...
Discussion. In this meta -analysis, we systematically summarize the effectiveness and side effects of different types of antidepressants. For the clinical efficacy and side effects of first-line antidepressants, anti-inflammatory drugs and ketamine, this article covers a comprehensive analysis.
This review may be used as an evidence base by those in public health, clinical practice, and research. This paper discusses key areas in depression research; however, an exhaustive discussion of all the risk factors and determinants linked to depression and their mechanisms is not possible in one journal article—which, by its very nature, a ...
Research paper. Antidepressants or running therapy: Comparing effects on mental and physical health in patients with depression and anxiety disorders ... Impact of depression and antidepressant treatment on heart rate variability: a review and meta-analysis. Biol. Psychiatry, 67 (2010), pp. 1067-1074. View PDF View article View in Scopus Google ...
1. Introduction. Depression is a common disorder in late life that can reduce quality of life, and increase disability and all-cause mortality (Craig Nelson, 2019).For people over 55, the average prevalence of depression was estimated to be 13, and 2% of these people were found to have major depression (Beekman et al., 1999).Antidepressant agents are currently one important option for treating ...
Widespread prescribing has not reduced mental disability or suicide, raising questions about the assessment of evidence on effectiveness and safety of antidepressants, writes John Warren Depression can be severe and reduce life expectancy. Antidepressant prescribing has increased substantially in recent years so that one in eight UK adults, some 7.3 million people, now receive a prescription ...
D.C. Steffens. N Engl J Med 2024;390:630-639. Treatment-resistant depression in older adults is common and can be difficult to manage. Strategies include ensuring adequate antidepressant therapy ...
The second edition of the e-book "The pharmacotherapy of depression-searching for new mechanisms and drug interactions" includes research and review papers. Three Reviews present the mechanisms of autophagy, ferroptosis, and mitophagy as a new strategy for treating depression (Lv et al.; Zhang et al.; Xu et al., respectively).Autophagy is a crucial mechanism of intracellular degradation ...
The clinical response to selective serotonin reuptake inhibitors (SSRIs) in depression takes weeks to be fully developed [].While it has been suggested that initial improvements in mood, or ...
Depression (also called major depression, major depressive disorder, or clinical depression) is diferent. It can cause severe symptoms that afect how a person feels, thinks, and handles daily activities, such as sleeping, eating, or working. Depression can afect anyone regardless of age, gender, race or ethnicity, income, culture, or education.
In that randomized trial of over 200 participants with depression, adults who took gepirone on average experienced a 9.04-point decrease in the 17-item Hamilton Depression Rating Scale (HAMD-17) after eight weeks, compared with a 6.75-point decrease among adults who took placebo. These findings were not enough to convince the FDA, which in 2002 ...
Introduction. Treatment guidelines like those published by National Institute for Health and Care Excellence (NICE) or the American Psychiatric Association (APA) strongly recommend long-term maintenance treatment in people with (or at risk of) recurrent depression to prevent relapses. 1,2 In accordance with these recommendations, the rate and duration of antidepressant use is steadily ...
It seemed to work: Antidepressants and electroconvulsive therapy often made the animal try harder. The test remains popular, appearing in about 600 papers per year. But researchers have recently begun to question the assumption that the test really gauges depression and is a good predictor of human responses to drugs.
More information: Stephanie T. Gumuchian et al, Fear of depression recurrence among individuals with remitted depression: a qualitative interview study, BMC Psychiatry (2024). DOI: 10.1186/s12888 ...
Treating anxiety and depression reduced emergency room visits and rehospitalizations among people with heart disease, according to new research published today in the Journal of the American Heart ...
Depression is a growing global crisis, with females at a higher rate of diagnosis than males. While the percentage of patients on prescribed antidepressants have tripled over the last two decades ...
March 17, 2024, 3:00 AM PDT. By Erika Edwards. Teenage boys are drowning in just as much of the depression and anxiety that's been well documented in girls. Experts warn that many young men ...
A new study in Biological Psychiatry finds that treating depression may significantly reduce the later risk of developing dementia. The research suggests both antidepressants and psychotherapy can ...
Analysis of Published Papers. In the past decade, the total number of papers on depression published worldwide has increased year by year as shown in Fig. Fig.1A. 1 A. Searching the Web of Science database, we found a total of 43,863 papers published in the field of depression from 2009 to 2019 (search strategy: TI = (depression$) or ts = ("major depressive disorder$")) and py = (2009-2019 ...