About Series GRM

Series GRM Clamps are designed specifically for handling sheet metal in stamping/fabricating press applications. A compact size makes the Series GRM Clamp ideal for applications in confined work areas.

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Maximum Saved Studies Reached

A Clinical Study of the Pharmacokinetics and Safety of BCD-263 and Opdivo® as Monotherapy in Subjects With Advanced Melanoma of the Skin

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Following screening, subjects will be randomized to receive either BCD-263 or Opdivo in a 1:1 ratio and enter the main study period.

During the main study period, subjects will receive therapy with BCD-263 or Opdivo, which will be administered intravenously until disease progression or signs of unacceptable toxicity develop (whichever occurs earlier).

At Week 25, after completion of all scheduled procedures subjects in both groups will continue to receive open-label BCD-263 for up to a total of 2 years of therapy, or disease progression, or signs of unacceptable toxicity (whichever occurs first).

Following discontinuation of the study therapy, the subjects will enter a follow-up period, during which data on overall survival will be collected through telephone contacts.

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Inclusion Criteria:

  • Age ≥18 years at the time of signing the informed consent form;
  • Body weight 60 to 90 kg.

Histologically confirmed melanoma with the following prognostic characteristics:

  • LDH <ULN of local laboratory (enrollment of subjects with LDH <2x ULN of local laboratory is allowed until the number of subjects with LDH >ULN is 30% of the total population of randomized subjects. The Sponsor will inform when enrollment of subjects is limited by LDH level <ULN of the local laboratory).
  • Absence, according to the Investigator, of clinically significant symptoms associated with the tumor.
  • Absence, according to the Investigator, of rapidly progressing metastatic melanoma.
  • Newly diagnosed advanced unresectable (stage III) or metastatic disease (stage IV), or progressive disease during / relapsing after radical treatment.

Exclusion Criteria:

  • Indications for radical treatment (surgery, radiation therapy).
  • Uveal or mucosal melanoma.
  • Previous systemic anticancer therapy for advanced unresectable or metastatic skin melanoma (a history of neoadjuvant or adjuvant therapy is allowed, provided that the therapy was completed at least 12 weeks before randomization).
  • Active CNS metastases and/or carcinomatous meningitis.
  • Previous invasive cancer, excluding diseases treated with potentially curative therapy with no evidence of recurrence for 2 years from the start of this therapy (subjects with radically resected basal cell carcinoma of the skin, superficial bladder cancer, squamous cell carcinoma of the skin, cervical carcinoma in situ of the uterus and other carcinomas in situ may be included).
  • Subjects with severe concomitant disorders, life-threatening acute complications of the primary disease (including massive pleural, pericardial, or peritoneal effusions requiring intervention, pulmonary lymphangitis, bleeding or organ perforation) at the time of signing the informed consent and during the screening period.
  • Concomitant diseases and/or conditions that significantly increase the risk of adverse events (AEs) during the study.

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PHD Manufacturing

PHD Manufacturing is "The Preferred Source" manufacturer of hangers, bracing, and more for the Fire Sprinkler Industry

Phd manufacturing expert:   1-800-321-2736.

2001-2496

I.P. Pipe Clamps

Figure: 2001 - 2016

Material: Low Carbon Steel, Available In Aluminum And Stainless Steel

Finish: Electro-Galvanized

ORDERING:  Specify figure number.

View Data Sheet

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  2. Product

    PHD, Inc. Request a Quote. Series PFC Pneumatic Frame Clamps feature a rugged cam design that provides consistent clamping force of up to 11,250 pounds throughout a wide power window. A wide jaw throat accommodates large parts with simple tooling. Series PFC Clamps are designed to clamp heavy parts such as the frame of an automobile.

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    The forming clamps press the bottom frame section onto the top frame section until the seams overlap and provide an even seam for welding. APPLICATION ... PHD, Inc. 9009 Clubridge Drive P.O. Box 9070, Fort Wayne, Indiana 46899 U.S.A. Phone (260) 747-6151 • Fax (260) 747-6754

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    PHD designs and manufacturers pneumatic, hydrauli,c and electrical grippers & actuators for Industrial Automation. 1-800-624-8511 ... Series GRM Clamps are designed specifically for handling sheet metal in stamping/fabricating press applications. A compact size makes the Series GRM Clamp ideal for applications in confined work areas. Example ...

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  17. A Clinical Study of the Pharmacokinetics and Safety of BCD-263 and

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